Pathophysiology of Heart and Circulatory System


Course Objective

The aim of this course is to provide students with insight into the
functioning of the cardiovascular
system, the pathogenesis of the major cardiovascular diseases and in
the possibilities for therapeutic intervention. Pathomechanisms are
discussed that that can lead to the development of myocardial infarction
and heart failure, mechanisms of genetic heart disease and the role of
co-morbidities in cardiac disease.

Course Content

The course consists of the following subjects:
- Macrocirculation and atherosclerosis
- Microcirculation and vasoregulation
- Heart function and myocardial infarction
- Cardiomyopathies
- Angiogenesis and arteriogenesis

In the first part of the course, the properties of macrocirculation
(atherosclerosis) and microcirculation (organ level) and their
regulation are discussed, and the changes in the vessel wall that may
lead to increased
blood pressure and atherosclerosis.
In the second part, the heart's action on molecule, cell and
and organ level are discussed, the abnormalities (pathomechanisms) that
arise and different forms of acquired and inherited cardiac disease.
In the third part, the regulation of the barrier function of blood
vessels is discussed and the role of angiogenesis and arteriogenesis.

Teaching Methods

Lectures: 18 hours
Practical courses: 6 hours
Workgroups: 10 hours

Method of Assessment

Report of research proposal & presentation: 20%
Exam: 80%

The two components of the test can be compensated and together they must
be sufficient.


Cardiophysiology concepts, 2nd edition, Richard E Klabunde.

Target Audience

Bachelor students Biomed, G&L, GZW, 2nd year or higher.

Additional Information

For students who will (possibly) choose the Master Cardiovascular
Research, this course is strongly recommended.

Custom Course Registration

Workgroups and practicals: see Canvas

Explanation Canvas

Practical manuals and study assignments are provided via Canvas

Recommended background knowledge

Sufficient and demonstrable knowledge of the physiology and anatomy of
cardiovascular and respiratory system (e.g. Biomed course; Human anatomy
and physiology' or GZW course CRS)

General Information

Course Code AB_1015
Credits 6 EC
Period P5
Course Level 200
Language of Tuition English
Faculty Faculty of Science
Course Coordinator J.M. de Winter MA
Examiner prof. dr. J. van der Velden
Teaching Staff dr. P. Koolwijk
dr. E.C. Eringa
prof. dr. J. van der Velden
dr. D.W.D. Kuster
prof. dr. P.L. Hordijk MA
J.M. de Winter MA
R.A. Boon MA

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar, Lecture, Study Group, Practical
Target audiences

This course is also available as: