Advanced Clinical Neurosciences


Course Objective

The overall aim of the Advanced Clinical Neuroscience course is to learn
how to design, perform and critically evaluate clinical neuroscience.
Specific learning goals are as follows:
1. The student is able to design and interpret clinical neuroscientific
1.1 The student is able to list the most important clinical features of
the five diseases/disorders that are central to this course (Alzheimer’s
disease, Parkinson’s disease, multiple sclerosis, brain tumors, selected
psychiatric disorders)
1.2 The student is able to identify relevant diagnostic and treatment
problems within these diseases/disorders
1.3 The student is able to construct hypotheses directed at solving
these diagnostic problems
1.4 The student can design a research study about a clinical
neuroscientific topic
2. The student can perform clinical neuroscientific research
2.1 The student can recite techniques and methods used within
2.2 The student is able to apply and administer these methods within the
five main diseases/disorders
2.3 The student can argue what the correct statistics are to test
his/her hypotheses
3. The student is able to critically evaluate clinical neuroscientific
3.1 The student is able to formulate pros and cons of a research
3.2 The student is able to apply their knowledge to criticize the
scientific quality of clinical neuroscientific papers

Course Content

This course will involve lectures, workshops and clinical observation to
familiarize students further with clinical neuroscience. They are
expected to design and present a neuroscientific study of their own
interest. They will integrate the current scientific state of the art
with clinical patient presentation in a written case report. They will
also gain experience in the process of peer review.

Teaching Methods

Lectures (10 contact hours)
For each of the five main diseases/disorders, a clinical lecture will
focus on a stringent/current problem that needs solving or will feature
a patient. We assume basic knowledge on each diseases/disorders, so that
we can discuss the problem in depth. Every clinical lecture is paired
with a research lecture, in which an (innovative) approach towards
solving a (perhaps not the same) problem. The students are expected to
prepare a single paper for each lecture and may be quizzed on their
preparation during the lecture.

Clinical observation (4-8 contact hours)
For further familiarization with the clinical aspects of neuroscience,
students will be able to observe a patient visit (either clinical or
research-related) in duo’s.

Clinical neuroscience methods workshops (8 contact hours)
In order to further provide students with the tools necessary to conduct
clinical neuroscience, a series of hands-on workshops will be taught.
Topics include brain stimulation, animal studies, neuropsychological
testing, scientific writing and presenting, epidemiology and trial
design, peer-review etcetera. Participation during these workshops is
essential for optimal performance in the course.

Method of Assessment

• Scientific abstract presentation (30% of final grade)
• Peer review assignment (30% of final grade)
• Written case report (40%)
• NB all three components have to be awarded a sufficient grade (5.5 or
higher) in order to receive a sufficient final grade.

Entry Requirements

Clinical Neuroscience (470757)


A number of recent relevant reviews, peer-reviewed articles and chapters
will be posted on Canvas.

Target Audience

Msc Neurosciences students, 2nd year following Track Clinical
Other Msc Neurosciencse students with interest in Clinical

Additional Information

There is a maximum of 25 students. For further information and
application, please contact the course coordinators: dr. Linda Douw or
dr. Chris Vriend (

Custom Course Registration

Registration via VUnet, please inform us ( if you switch after signing up through VUnet! NB students who did not do Clinical Neuroscience (470757) should contact the course coordinators before enrolling.

General Information

Course Code AM_1014
Credits 6 EC
Period P1
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. L. Douw
Examiner dr. L. Douw
Teaching Staff dr. L. Douw

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar, Lecture, Study Group