Macroscopic, microscopic and pathological anatomy of the mouse


Course Objective

Animal experiments, especially using mice and rats, are an important
part of many PhD projects. A better understanding of rodent anatomy,
histology, pathology, genetics, wellbeing, and a proper perspective of
the difference of rodent models versus human physiology can improve the
quality of these experiments substantially.

Course participants are introduced into various aspects of research with
rodents. The aim is to increase awareness of the physiology and genetics
of experimental animals, thereby enabling better planning and execution
of animal research.

After finishing this course, students:
- Can describe and demonstrate the anatomy and histology of major organs
of the mouse;
- Are able to choose mouse strains suitable for their research;
- Can interpret histological and imaging data;
- Can judge behaviour and deduce wellbeing of experimental animals;
- Can design mouse experiments that are better suited for translation to

Course Content

The subjects covered are:
1. Anatomy (dissection) of adult male and female mice.
2. Microscopic and pathological anatomy of rodent tissues and organs.
3. Dealing with pathologically changed animals.
4. Developmental anatomy; comparison of rodent and human anatomy.
5. Imaging the mouse (MRI).
6. Gene targeting, transgenic strategies, and generation of mouse
7. Gene targeting, transgenic strategies, and generation of mouse
8. Mouse breeding and querying the Jax phenotype database.
9. Rodent behavior and experimental outcomes.

Teaching Methods

Master students have to make an assignment.

Target Audience

OOA courses are open for Master Oncology students as optional courses
under certain conditions.
PhD candidates, postdocs and technicians are also welcome.

Additional Information

Course coordinators:
Dr. J.E. Seppen / Tytgat Institute for Liver and Intestinal Research / / tel. +31 (0)20 - 566 5405.

Prof.dr. V.M. Christoffels / Dept. Medical Biology / / tel. +31 (0)20 - 566 7821.

More information:
From the coordinators or E.M. de Greef:
Contact: AMC Graduate School / E-mail:
Tel: +31 (0)20 - 566 3108

Custom Course Registration

This course is organized and coordinated by the Tytgat Institute for Liver & Intestinal Research and the Department of Medical Biology, in collaboration with the Oncology Graduate School of Amsterdam (OOA, Onderzoekschool Oncologie Amsterdam). The course is incorporated in the course program of the AMC Graduate School for Medical Sciences. Participants follow lectures in the morning and learn hands-on skills in the afternoon. The course lasts 5 days and takes place once a year. Studyload: 40 hours, which is comparable to 1.5 ECTS points. Scheduled dates: 20 thru 24 April, 2020. Application: Via the Tytgat Institute; Ms Elsa de Greef / Tytgat Institute for Liver and Intestinal Research / / tel. +31 (0)20 - 566 5948.

General Information

Course Code M_OMAMIPAT18
Credits 3 EC
Period P5
Course Level 500
Language of Tuition English
Faculty VUmc School of Medical Sciences
Course Coordinator
Teaching Staff

Practical Information

You need to register for this course yourself

Teaching Methods Lecture, Study Group
Target audiences

This course is also available as: