Course ObjectiveCompetences covered according to the General Educational Framework
Dentistry 2008: II c-i (4)
The student has
• insight in the different study designs, and methods of advanced
etiologic, diagnostic and intervention (treatment and prevention)
scientific research. Hence the student will be able to define research
questions to perform scientific research on diagnostic accuracy and
intervention effectiveness independently and take well-motivated
decisions on which design is best to use.
• expertise and insight in the importance of a research proposal.
Moreover, the student is able to
o compile a brief summary of the evidence from scientific research in a
comprehensive and transparent manner as introduction of the proposal and
o write an appropriate research question, based on the research gap that
will be studied,
o choose an appropriate design to be able to provide an answer to that
question, based on the pros and cons of every design,
• expertise in deriving ‘best-available evidence’ from published
original scientific research by interpreting and appreciating the
relevance and quality of this published scientific research.
• proficiency in the approach to the complex concepts of measures of
disease frequency (prevalence, incidence) along with simple risk
Course ContentWith this course the students should be able to perform scientific
research in the upmost highest quality, as well as being able to
distinguish between poor and high quality published scientific research.
With this knowledge, the students are able to make choices in their
treatment based on the best evidence available. Competencies obtained
during this course will provide students with advanced understanding and
deep insights that will help them to meet the challenges of the 21st
century health care and research, and apply these properly in delivering
Evidence Based best practice in dentistry and oral health care.
Teaching MethodsSelf-study; Lectures; Work groups; Assignments
Method of AssessmentLearning assessments
• Research proposal (grade: good; pass; or fail)
• Written exam: open ended and case based exam questions (grade: 1-10)
• A prerequisite for grade registration (grade 1-10) is for the research
proposal to be graded as good or pass. In case of a fail for the
research proposal and a pass for the final exam, a 5.0 will be
registered and students will need to rewrite the research proposal.
Literature• MM ter Wee & BI Lissenberg-Witte. A Quick Guide on How to Conduct
Medical Research. From Set-Up to Publication. 2019. Bohn Stafleu van
Loghum. ISBN/ISSN 9789036822473.
• Methodological literature: selected methodological and background
fundamental papers (compulsory)
• Applied scientific literature: selected applied scientific research
papers for working groups (compulsory)
Additional InformationSession 1: Lecture on writing a research proposal
• Research question
• Design, Measurements, Analyses plan
Session 2: Lecture on research design / non-inferiority /
intention-to-treat / per protocol
• RCT, Cohort, Case control
• Non-inferiority, intention-to-treat
• Which steps do you need to follow when setting-up research?
Session 3: Lecture on quality of published articles / critical appraisal
• How do you critically appraise current literature?
Session 4: Systematic reviews
• Lecture: Systematic reviews: How do you perform a systematic review?
• Practical: Systematic reviews: Perform a small review using RevMan
Session 5: Lecture on statistics, the basics
• Prevalence, incidence descriptive statistics, OR, RR
Session 6: Diagnostic accuracy
• Lecture: Diagnostic accuracy
o Sensitivity, specificity,
o PPV, NPV, ROC curve, agreement
• Practical: Diagnostic accuracy and statistics in the basics
o Applying basic statistics and diagnostic accuracy
Session 7: Research participants & Judging research proposals
• Lecture: Research participants
o Why do we have laws, how to include patients, in- and exclusion
• Practical: Judging research proposals
o Judging each other’s proposal conform a rubric
|Period||Ac. Year (sept)|
|Language of Tuition||English|
|Faculty||Faculty of Dentistry|
|Course Coordinator||dr. P. Wetselaar|
|Examiner||dr. P. Wetselaar|
You need to register for this course yourself
|Teaching Methods||Study Group*, Other*, Lecture*|
*You cannot select a group yourself for this teaching method, you will be placed in a group.