Advanced Course on Drug Disp. & Safety Assessment (Mol.Tox.)

2019-2020

Course Objective

Utilisation of knowledge of chemical properties and biological
interactions for application to drug development, hazard identification
and risk assessment.

Course Content

The course looks at pharmacology and toxicology from different view
points, chemical-centric, tissue-centric and pathway centric. The course
is designed to facilitate application of knowledge utilising a series of
case study assignments. These will include:

(1) Chemical properties and descriptors for determination of risk of
toxicity.
(2) Tissue specific properties for determination of pharmacology,
metabolism and sensitivity to chemical induced toxicity.
(3) Analysis of transcriptomic data for determining biological effects
of selected chemicals.
(4) Principles required for Adverse Outcome Pathway building and
deployment.

Teaching Methods

Case study based assignments, presentations, data analysis and
discussions.

Method of Assessment

70 % assignment based, 30 % exam.

Literature

Bal-Price and Jennings. In Vitro Toxicology Systems. Editors: (Eds.)
Springer (ISBN 978-1-4939-0521-8).
Casarett, and Doull, Toxicology: The Basic Science of Poisons 8th ed.
New York: Pergamon Press (ISBN 987-0-07-176925-9).
Other sources including online lectures provided through Canvas

Target Audience

mDDS-DDSA, mDDS-DDTF, others interested in toxicological principles

Recommended background knowledge

Courses 'ADMET' and 'Drug-induced stress and Cellular Responses', or
equivalent courses are highly desirable but not mandatory.

General Information

Course Code X_435681
Credits 6 EC
Period P5+6
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator prof. dr. P. Jennings
Examiner prof. dr. P. Jennings
Teaching Staff prof. dr. P. Jennings

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar
Target audiences

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