Course ObjectiveUtilisation of knowledge of chemical properties and biological
interactions for application to drug development, hazard identification
and risk assessment.
Course ContentThe course looks at pharmacology and toxicology from different view
points, chemical-centric, tissue-centric and pathway centric. The course
is designed to facilitate application of knowledge utilising a series of
case study assignments. These will include:
(1) Chemical properties and descriptors for determination of risk of
(2) Tissue specific properties for determination of pharmacology,
metabolism and sensitivity to chemical induced toxicity.
(3) Analysis of transcriptomic data for determining biological effects
of selected chemicals.
(4) Principles required for Adverse Outcome Pathway building and
Teaching MethodsCase study based assignments, presentations, data analysis and
Method of Assessment70 % assignment based, 30 % exam.
LiteratureBal-Price and Jennings. In Vitro Toxicology Systems. Editors: (Eds.)
Springer (ISBN 978-1-4939-0521-8).
Casarett, and Doull, Toxicology: The Basic Science of Poisons 8th ed.
New York: Pergamon Press (ISBN 987-0-07-176925-9).
Other sources including online lectures provided through Canvas
Target AudiencemDDS-DDSA, mDDS-DDTF, others interested in toxicological principles
Recommended background knowledgeCourses 'ADMET' and 'Drug-induced stress and Cellular Responses', or
equivalent courses are highly desirable but not mandatory.
|Period||P5+6, Ac. Year (sept)|
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. P. Jennings|
|Examiner||prof. dr. P. Jennings|
prof. dr. P. Jennings
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