This course is offered in Dutch. Some of the descriptions may therefore only be available in Dutch.
Course ObjectiveThe properties of cells and higher levels of organisation emerges out of
molecular interactions within huge networks. Examples of such molecular-
reaction networks are: metabolism, signal transduction, and gene
networks. Systems biology studies the principles of such networks using
quantitative experiments, computer modelling and theory.
The aim of this course is to introduce the students to the approach
taken in systems biology. We will study a number of theoretical findings
of systems biology about the dynamics and regulation of molecular
networks inside living cells using small "toy" mathematical models and
basic principles of biochemistry and physics.
Course ContentThe following topics will be discussed:
- mass-action kinetics and basic enzyme kinetics
- thermodynamic equilibrium and steady state
- dynamics of simple systems
- protein complex formation, allosteric interactions, and cooperativity
- ultrasensitivity of small signalling circuits
- supply and demand as coarse-grained method to dissect regulation of
- robust integral feedback control
- role of positive and negative feedback
The practicals involve answering exercises and basic plotting of results
of mathematical models.
Teaching Methodslecture series and supervised work groups in which assignments from the
syllabus are made
Method of AssessmentWritten exam (open book). Learned techniques will have to be applied to
Entry RequirementsBasic knowledge of mathematics (differential equations, differentiation,
formula manipulation), (bio-)chemistry, and cell biology.
LiteratureSyllabus (gratis via BB)
Target AudienceStudents interested in the intricate workings of biological systems and
not afraid of basic equations describing the properties of dynamic
|Language of Tuition||Dutch|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. B. Teusink|
|Examiner||prof. dr. B. Teusink|
prof. dr. B. Teusink
prof. dr. F.J. Bruggeman
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Lecture, Practical|
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