Course ObjectiveAt the end of this theoretical course, the students are aware of the
latest insights of cellular stress responses which can occur after
exposure of cells to reactive drugs and/or reactive drug metabolites.
Course ContentExposure of tissues to high levels of drugs and/or drug metabolites in
some cases can trigger various biochemical responses. Interaction with
sensor proteins can lead to adaptative stress responses which will
protect the cell against further damage. If these adaptative stress
responses are insufficient, interaction with critical proteins may lead
to cell death or exaggerated, fatal pharmacological responses.
The following aspects will be studied in the course drug-induced stress
and cellular signaling:
• (types of) adverse drug reactions
• role of biotransformation and drug transport in adverse drug
• reversible and irreversible interactions of toxic drugs with
• cellular adaptation to exposure to reactive chemicals and reactive
• cellular and molecular mechanisms leading to toxic effects,
• role of mitochondria in necrosis and apoptosis,
• immune-mediated toxicity.
• advantages and disadvantages of different (novel) in vitro models used
in toxicity studies.
• cellular parameters reflecting stress-responses and mitochondrial
Teaching MethodsLectures, assignment and self study.
Method of AssessmentWritten exam and assignment
Entry RequirementsBachelor Pharmaceutical Sciences, Biomedical Sciences , Medical Natural
Sciences, Medical Biology or equivalent
LiteratureBoelsterli, Mechanistic Toxicology: The Molecular Basis of How Chemicals
Disrupt Biological Targets 2nd ed, CRC Press, 2007 (ISBN 0849372720).
Recent literature will be provided
Target AudienceMaster students Drug Discovery and Safety and Biomolecular Sciences
Custom Course RegistrationRegistration by VU-Net
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||dr. J.N.M. Commandeur|
|Examiner||dr. J.N.M. Commandeur|
prof. dr. P. Jennings
dr. J.N.M. Commandeur
dr. ir. J.C. Vos
dr. A. Wilmes
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