Course ObjectiveUtilisation of knowledge of chemical properties and biological
interactions for risk assessment.
Course ContentThe course will deal with principles involved in chemical-induced
toxicity including absorption, distribution, metabolism and elimination.
This will include:
Chemical properties and descriptors for determination of risk of
Organ specific properties for determination of sensitivity to chemical
Analysis of transcriptomic data for risk assessment.
Principles required for Adverse Outcome Pathway development and
Teaching MethodsAssignments, discussions, data analysis, case studies
Method of AssessmentAssignment based.
Entry RequirementsCourses 'ADMET' and 'Drug-induced stress and Cellular Responses', or
equivalent courses are desirable but not mandatory.
LiteratureBal-Price and Jennings. In Vitro Toxicology Systems. Editors: (Eds.)
Springer (ISBN 978-1-4939-0521-8).
Casarett, and Doull, Toxicology: The Basic Science of Poisons 8th ed.
New York: Pergamon Press (ISBN 987-0-07-176925-9).
Other sources including online lectures provided through Canvas
Target AudiencemDDS-DDSA, mDDS-DDTF, others interested in toxicological principles
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. P. Jennings|
|Examiner||prof. dr. P. Jennings|
prof. dr. P. Jennings
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