Advanced Course on Drug Disp. & Safety Assessment (Mol.Tox.)

2018-2019

Course Objective

Utilisation of knowledge of chemical properties and biological
interactions for risk assessment.

Course Content

The course will deal with principles involved in chemical-induced
toxicity including absorption, distribution, metabolism and elimination.
This will include:

Chemical properties and descriptors for determination of risk of
toxicity.
Organ specific properties for determination of sensitivity to chemical
induced toxicity.
Analysis of transcriptomic data for risk assessment.
Principles required for Adverse Outcome Pathway development and
verification.

Teaching Methods

Assignments, discussions, data analysis, case studies

Method of Assessment

Assignment based.

Entry Requirements

Courses 'ADMET' and 'Drug-induced stress and Cellular Responses', or
equivalent courses are desirable but not mandatory.

Literature

Bal-Price and Jennings. In Vitro Toxicology Systems. Editors: (Eds.)
Springer (ISBN 978-1-4939-0521-8).
Casarett, and Doull, Toxicology: The Basic Science of Poisons 8th ed.
New York: Pergamon Press (ISBN 987-0-07-176925-9).
Other sources including online lectures provided through Canvas

Target Audience

mDDS-DDSA, mDDS-DDTF, others interested in toxicological principles

General Information

Course Code X_435681
Credits 6 EC
Period P5+6
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator prof. dr. P. Jennings
Examiner prof. dr. P. Jennings
Teaching Staff prof. dr. P. Jennings

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar
Target audiences

This course is also available as: