Synthetic Approaches in Medicinal Chemistry

2018-2019

Course Objective

To obtain detailed knowledge of vital organic reactions and synthetic
strategies.

Course Content

Within a medicinal chemistry context, organic synthesis continues to
play a vital role because it allows perceived organic molecules to
actually be prepared. A medicinal chemist with thorough knowledge of the
synthetic toolbox will be able to efficiently find his/her way to a
target molecule.
First, a brief recap of some synthesis principles is offered. Then, the
course will focus on the most important and generally used synthetic
reactions. These include reactions of nucleophilic carbon intermediates,
nucleophilic substitutions, electrophilic additions to carbon-carbon
multiple bonds, reductions, oxidations, cycloadditions, aromatic
substitution reactions, rearrangements, and reactions of transition
metals as well as of Group I and II metals. Collectively, this course
delivers the synthetic knowledge necessary for efficient synthesis of
organic molecules.

Teaching Methods

The "Flipped classroom method" is used.

This means that all lectures have been recorded (slides + audio) and
need to be independently studied by the students (there are no regular
classes). Rather, all contact hours are used for intensive problem
solving sessions.

Method of Assessment

Written examination(s).

Entry Requirements

Basic knowledge of organic chemistry.

Literature

Carey, F.A., Sundberg, R.J., Advanced Organic Chemistry, Part B, 5th
edition.

Target Audience

mDDS, DD&S

Custom Course Registration

VUNet

General Information

Course Code X_435685
Credits 6 EC
Period P2
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. M. Wijtmans
Examiner dr. M. Wijtmans
Teaching Staff dr. M. Wijtmans
prof. dr. I.J.P. de Esch

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Lecture
Target audiences

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