Microbial Genomics


Course Objective

1. After the lecture series the students obtained insight in:

- The historical development of microbiological sciences
- Techniques to explore the human microbiome
- Human – Microbe interactions in Health and Disease
- Metabolic strategies of microorganisms
- Interventions with probiotics, prebiotics and synbiotics

2. Students have gained experience on thinking and writing about the
impact of microbes on either our environment, human health, or
industrial applications.

Course Content

During 10 lectures, the enormous diversity of microbial life will become
evident. The lectures will include a number of ways to explore microbial
life forms associated with our body, in particular related to health and
disease. Applications of our knowledge on the human microbiota for
diagnostics, prognostics and interventions will be discussed.

10 lectures (obligatory) including a 4-5 p. perspective

Teaching Methods

10 lectures (obligatory) including a 4-5 p. perspective

Method of Assessment

Each student will write a perspective (approximately 4-5 pages) for of
one of the 10 lectures; the abstract will containing a 1 page summary
of the lecture, and 3 pages on the relevance of the microbiological
topic for society (with particular emphasis on human heath). The
selected lecture will be announced after the final lecture.

Entry Requirements

Molecular Biology


Selected papers:

Kort R, Caspers M, van de Graaf A, van Egmond W, Keijser B, Roeselers G.
Shaping the oral microbiota through intimate kissing. Microbiome. 2014

Budding AE, Grasman ME, Lin F, Bogaards JA, Soeltan-Kaersenhout DJ,
Vandenbroucke-Grauls CM, van Bodegraven AA, Savelkoul PH. IS-pro:
molecular fingerprinting of the intestinal microbiota. FASEB J. 2010

Borgdorff H, Tsivtsivadze E, Verhelst R, Marzorati M, Jurriaans S,
GF, Schuren FH, van de Wijgert JH. Lactobacillus-dominated
microbiota associated with reduced HIV/STI prevalence and genital HIV
viral load
in African women. ISME J. 2014 Sep;8(9):1781-93.

Dutilh BE. Metagenomic ventures into outer sequence space.
Bacteriophage. 2014
Dec 15;4(4):e979664.

Belzer C, Gerber GK, Roeselers G, Delaney M, DuBois A, Liu Q, Belavusava
Yeliseyev V, Houseman A, Onderdonk A, Cavanaugh C, Bry L. Dynamics of
microbiota in response to host infection. PLoS One. 2014 Jul

Target Audience

MSc Students BioMolecular Sciences

Additional Information

Venue: Artis de Volharding


Announcement of lecture series:


Lecture topics and speakers:

Microbiome in Health and Disease
Monday Jan 4 (10.00 – 12.00 u)
Prof. Remco Kort (TNO, VUA). Introduction into the human microbiome.
Dries Budding, MD (VUMC). Man and Microbe: a delicate superorganism
Tuesday Jan 5 (10.00 u – 12.00 u)
Dr. Douwe Molenaar (VUA). Dealing with big data of the microbiota.
Dr. Evgeni Levin-Tsivtsivadze (TNO). Microbial ecology in health and
disease: a machine learning approach.
Friday Jan 8 (10.00 u – 12.00 u)
Dr. Bas Dutilh (UU). Metagenomic ventures into outer sequence space.
Dr. Guus Roeselers (TNO). Microbial ecology of the gastro-intestinal
Monday Jan 11 (10.00 – 12.00)
Prof. Eddy Smid (WUR). The best foods are made by microbes.
Prof Wilbert Bitter (VUMC) Die hard with a vengeance, strategy of
mycobacterial pathogens.
Tuesday Jan 12 (10.00 – 12.00)
Prof. Janneke van de Wijgert (University of Liverpool, Institute of
Infection and Global Health). Microbial ecology of bacterial vaginosis.
Prof. Gregor Reid (Canadian Centre for Human Microbiome and Probiotic
Research, Lawson Health Research Institute). Fermented milk as a
delivery vehicle for probiotics in Africa.

Recommended background knowledge

General and Molecular Microbiology

General Information

Course Code AM_1021
Credits 3 EC
Period P3
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator prof. dr. R. Kort
Examiner prof. dr. ir. R. Kort
Teaching Staff

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Lecture
Target audiences

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