Macroscopic, Microscopic and Pathological Anatomy of the Mouse


Course Objective

Animal experiments, especially using mice and rats, are an important
part of many PhD projects. A better understanding of rodent anatomy,
histology, pathology, genetics, wellbeing, and a proper perspective of
the difference of rodent models versus human physiology can improve the
quality of these experiments substantially.

Course participants are introduced into various aspects of research with
rodents. The aim is to increase awareness of the physiology and genetics
of experimental animals, thereby enabling better planning and execution
of animal research.

After finishing this course, students:
- can describe and demonstrate the anatomy and histology of major organs
of the mouse;
- are able to choose mouse strains suitable for their research;
- can interpret histological and imaging data;
- can judge behaviour and deduce wellbeing of experimental animals;
- can design mouse experiments that are better suited for translation to

Course Content

The subjects covered are:
1.Anatomy (dissection) of adult male and female mice
2.Microscopic and pathological anatomy of rodent tissues and organs
3.Dealing with pathologically changed animals
4.Developmental and neuro-anatomy: comparison of rodent and human
5.Imaging the mouse (MRI and PET/SPECT)
6.Gene targeting, transgenic strategies, and generation of mouse models
7.Mouse breeding and querying the Jax phenotype database
8.Rodent behaviour and experimental outcomes

Method of Assessment

Master students have to make an assignment.

Target Audience

This is a PhD-students' course organized by the OOA. OOA courses are
open for Master Oncology students as optional courses under certain

Additional Information

For further information contact:

Dr. J.E. Seppen
Course coordinator
Tytgat Institute for Liver and Intestinal Research

Dr. E.A.J. Reits
Course coordinator
Department of Cell Biology & Histology


Custom Course Registration

This course is organised and coordinated by the Tytgat Institute for Liver & Intestinal Research and the Department of Cell Biology & Histology, in collaboration with the Oncology Graduate School of Amsterdam (OOA, Onderzoekschool Oncologie Amsterdam). The course is incorporated in the course programme of the AMC Graduate School for Medical Sciences. Participants follow lectures in the morning and learn hands-on skills in the afternoon. The course lasts 9 days and takes place once a year. Attending both weeks is recommended, however, it is possible to attend only the first week (mouse anatomy, histology, pathology, and imaging) or the second week (mouse genetics, behaviour and scaling). Study load: 72 hours, which is comparable to 2.6 ECTS For further information and registration contact: Ms Mona Brox Edvardsen Tytgat Institute for Liver and Intestinal Research email:

General Information

Course Code M_OMACROS03
Credits 3 EC
Period Ac. Year (sept)
Course Level 500
Language of Tuition English
Course Coordinator
Teaching Staff

Practical Information

You need to register for this course yourself

Teaching Methods Lecture, Study Group
Target audiences

This course is also available as: