Tumor Biology and Clinical Behaviour

2018-2019

Course Objective

The aim of the course is to provide in depth knowledge of and insight in
the relationship between somatic DNA alterations, gene and protein
expression, and subsequent biology and clinical behavior of tumors.
Students will obtain a broad overview of (development of) theories in
this field of 'bench-to-bedside' translational research. Moreover,
students will be trained to develop an increasingly critical view on
published literature and to function as a critical peer review group
towards research project plans of colleagues.

Course Content

The course "Tumor Biology and Clinical Behavior" aims to provide in
depth knowledge of and insight in the relationship of gene expression,
biology and clinical behavior of tumors. Students will obtain a broad
overview of development of theories in this field of oncological
research. Moreover, students will be trained to develop an increasingly
critical view on published literature and to function as critical mass
towards research project plans of colleagues (peer review).

This course consists of three components:
1) Lectures given by experts on various topics of tumor biology and
clinical behavior,
comprising 'Biology of metastasis', 'Tumor profiling', 'Screening and
prevention',
and 'Molecular imaging'
2) Journal clubs that stimulate students to develop a critical view on
published
literature, using papers that span 'bench to bedside' research
3) Research proposals, in which students learn to design and present a
4-year PhD
student translational research project proposal.

Lectures will be given throughout the course by the organizers and guest
speakers. On the basis of their contents the lectures can be subdivided
into the topics 'Histopathology/epidemiology’, 'Tumor profiling and
biomarkers’,
bioinformatics/Biostatistics’, ‘Tumor-microenvironment
interactions’,‘Tumor cell
spread / Metastasis’, ‘Molecular Imaging’ and ‘Screening and
prevention’. Journal
clubs will be held during the first three weeks of the course, during
which one paper
will be discussed in detail.

Research proposals; students will present their progress on preparation
of a research proposal twice by Power Point presentations. Other
students will help to improve these proposals in workgroup discussions,
guided by tutors. The complete research proposal will be presented at
the end of the course. The remaining time during the course can be used
for preparation for Journal clubs, Research proposals, and study for
examination. Details of the preparation for the Journal clubs and
Research proposals are provided elsewhere in this reader.

Teaching Methods

50 hours, consisting of 32 lectures (1 hr each), 2 journal club
discussion groups
(2 hrs each), and 3 research proposal work groups (4hrs each). This
course is characterized by a high level of interactive education.
Students have to participate actively in discussion- and work-groups.

Method of Assessment

A major aspect of the course is preparation of a research proposal by
power-point presentation in groups of 2 students. Tutors will help in
preparing these proposals by detailed discussion sessions. The complete
proposal will be presented at the end of the course. Marks will be given
by both tutors and will determine 40% of the final
mark. The other 60% of the assessment will be done by an exam,
consisting of assay questions, covering the major topics of the
lectures.

Students have to attend all sessions during the course. Active
participation is absolutely required.

Literature

The course material consists of recent reviews in the field of gene
expression, biology and clinical behavior of tumors.

Target Audience

The course is compulsory for students of the Master in Oncology
External candidates are also allowed, if accepted by the program
oordinator.Students from other master programs must have basic knowledge
of Oncology and Immunology and will only be accepted when the number of
master Oncology students is less than 40. They have to send their cv,
motivation and transcript of records via email to the program
coordinator. At the beginning of July 2018, students will be informed
about the acceptance.

Additional Information

Coördinators:
Dr. S.A.G.M. Cillessen
Prof.dr. E. Bloemena

Custom Course Registration

All students of the Master Oncology Program have to attend the compulsory courses of the program. For all your courses you must register through VUnet.vu.nl This way, you find out immediately if a place is available. All activities for which you are registered will be displayed in your personal timetable, which also includes any timetable changes. If you have not registered for a course then you will not be admitted to that course, you will not be assigned to a group, you will not be able to use CANVAS, you will have no timetable, your grades will not be recorded, etc. In short, you will not be able to take part. From the moment that you are conditionally registered for a programme, you can sign up for specific courses via VUnet.vu.nl

Recommended background knowledge

A solid basal knowledge of oncology is compulsory before the start of
the course.

General Information

Course Code M_OTBCB03
Credits 6 EC
Period P2
Course Level 400
Language of Tuition English
Faculty VUmc School of Medical Sciences
Course Coordinator prof. dr. E. Bloemena
Examiner dr. S.A.G.M. Cillessen
Teaching Staff

Practical Information

You need to register for this course yourself

Teaching Methods Seminar, Lecture