Advanced Analytical Sciences in Drug-Related and Clinical Environments


Course Objective

Giving a clear description on the instrumental and bio-analytical
techniques and strategies that are used in biomedical and clinical
analysis and diagnostics.

Course Content

The course will start with discussing the basics of bio-analytical and
clinical chemistry focusing on decision trees (strategic decisions) that
can be used during the method development and optimization of analytical
procedures to determine both endogenous and exogenous compounds in
complex biological samples. Approaches and procedure with respect to
sampling, sample preparation, separation, as well as immunological and
enzymatic procedures will be dealt with. Special attention will be given
to the simultaneous determination of parent compounds in the presence of
their degradation products, metabolites, precursors and/or structure
analogues. In addition to target finding, screening procedures in the
fields of metabolomics, proteomics, etc . will be highlighted. During
the course case studies will be used to clarify the decisions that have
to be taken using advanced bio-analytical and clinical determinations.

Teaching Methods

Lectures and tutorials

Method of Assessment

Written examination


M.L. Bishop, E.P. Fody, L.E. Schoeff, Clinical Chemistry, Wolters
Kluwer, Philadelphia, Sixth edition, 2010.

Target Audience

mDDS, mMNS, mCH-AS (however, not in combination with Bio-Analysis &
Clinical Diagnostics)

Additional Information

This course can not be followed in combination with Bio-Analysis &
Clinical Diagnostics.

Recommended background knowledge

Basic knowledge on analytical chemistry, biochemistry, chromatography,
electrophoresis and mass spectrometry

General Information

Course Code XM_0068
Credits 6 EC
Period P3
Course Level 400
Language of Tuition English
Faculty Faculty of Science
Course Coordinator prof. dr. G.W. Somsen
Examiner prof. dr. G.W. Somsen
Teaching Staff prof. dr. G.W. Somsen

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Lecture
Target audiences

This course is also available as: