Signal Transduction in Health and Disease


Course Objective

At the end of this theoretical course, the students are aware of the
latest insights of cellular signal transduction in both healthy and
pathological conditions.

Course Content

This course will link human genetic variations (somatic and inherited
mutations) to the development of disease and will focus on pathological
signaling, mutant signaling proteins in disease and possible treatment
of resulting disease (small molecules, biologicals, gene therapy).
Modern pharmacological concepts, including constitutive receptor
activity, receptor regulation, allosteric modulation and dimerization
will be addressed in light of signal transduction in health and disease.
A special focus will be on signal transduction resulting in pathologies
such as Alzheimer, Parkinson’s disease, inflammatory diseases and

Teaching Methods

Lectures, self-study, assignment(s)
Students will do a case study in groups focusing on a recent primary
research article, which focuses on a signaling pathway
linked to disease. Molecular mechanisms underlying the pathology need to
be addressed and presented. Therapeutic targeting of this signaling
pathway will be addressed and discussed.

Method of Assessment

Assignment/presentation, written exam.


'Cell signaling', Authors: Wendell Lim, Bruce Mayer, Tony Pawson
ISBN: 9780815342441
Format: Paperback
Publication Date: June 15, 2014

Research articles and additional theoretical background will be
available on Canvas

Target Audience

var, mDDS-E-var, mDDS-M-var, mMNS-MCD, mMNS-MPy

Recommended background knowledge

Bachelor Biology, Medical Biology, Pharmaceutical Sciences, Medical
Natural Sciences, Biomolecular Science portal course or equivalent

General Information

Course Code X_432535
Credits 6 EC
Period P2
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator prof. dr. M.J. Smit
Examiner prof. dr. M.J. Smit
Teaching Staff prof. dr. M.J. Smit
dr. ir. A.H. de Boer
dr. M.H. Siderius

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Lecture
Target audiences

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