Course ObjectiveAt the end of this theoretical course, the students are aware of the
latest insights of cellular signal transduction in both healthy and
Course ContentThis course will link human genetic variations (somatic and inherited
mutations) to the development of disease and will focus on pathological
signaling, mutant signaling proteins in disease and possible treatment
of resulting disease (small molecules, biologicals, gene therapy).
Modern pharmacological concepts, including constitutive receptor
activity, receptor regulation, allosteric modulation and dimerization
will be addressed in light of signal transduction in health and disease.
A special focus will be on signal transduction resulting in pathologies
such as Alzheimer, Parkinson’s disease, inflammatory diseases and
Teaching MethodsLectures, self-study, assignment(s)
Students will do a case study in groups focusing on a recent primary
research article, which focuses on a signaling pathway
linked to disease. Molecular mechanisms underlying the pathology need to
be addressed and presented. Therapeutic targeting of this signaling
pathway will be addressed and discussed.
Method of AssessmentAssignment/presentation, written exam.
Literature'Cell signaling', Authors: Wendell Lim, Bruce Mayer, Tony Pawson
Publication Date: June 15, 2014
Research articles and additional theoretical background will be
available on Canvas
Target AudiencemBMS-BC, mDDS-BCCA, mDDS-CMCT, mDDS-DD&S, mDDS-DDSA, mDDS-DDTF, mDDS-C-
var, mDDS-E-var, mDDS-M-var, mMNS-MCD, mMNS-MPy
Recommended background knowledgeBachelor Biology, Medical Biology, Pharmaceutical Sciences, Medical
Natural Sciences, Biomolecular Science portal course or equivalent
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. M.J. Smit|
|Examiner||prof. dr. M.J. Smit|
prof. dr. M.J. Smit
dr. ir. A.H. de Boer
dr. M.H. Siderius
You need to register for this course yourself
Last-minute registration is available for this course.
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