Course ObjectiveTo get students acquainted with modern chemical biology techniques to
study proteins and the modulation of their function, with a specific
emphasis on the various multidisciplinary aspects of drug discovery
Course ContentIn this introductory course emphasis will be given on the interface
and Biology in relation to the field of Drug Discovery. How can one
understand biological processes using small molecules? How can one
identify small molecules targeting new biochemical pathways, either by
using modern biochemical or cellular assays or in silico using the
wealth of new information from structural biology? How to detect and/or
modulate DNA, RNA and protein expression and/or function with chemical
probes? These are the questions that are central to this introductory
Teaching Methodslectures, tutorial, consultancy sessions and case study/presentation
Method of AssessmentStudents will work in small groups on an integrated case study. Based on
primary literature, background information from Comprehensive Medicinal
Chemistry, interaction with “Protein Champions”, students will work on a
“Chemical Biology Protein Report” and oral presentation for the rest of
the rest of the class.
Finally, there will be a written examination at the end of the course on
topics presented at the end of the course by fellow students, the
scheduled entry lectures and selected primary papers.
Final grades will be based on results of the case study (35%), case
presentation and discussion (15%) and final exam (50%). Each part must
at least be satisfactory (mark “6 out of 10” or higher).
Entry RequirementsBachelor Pharmaceutical Sciences, Medical Natural Science, Science,
Business and Innovation or Chemistry. Portal course MSc Biomolecular
Science or Principles of Pharmaceutical Sciences or equivalent for mBMS
students and students with
Bsc SBI or Chemistry.
With a BSc SBI or Chemistry, please contact prof. Leurs before
registration on your eligibility to participate.
LiteratureIn the course we will use mainly primary literature and handouts of
Target AudiencemBMS-BC, mCh-SBI (2nd year), mDDS-BCCA, mDDS-CMCT, mDDS-DD&S, mDDS-DDSA,
mDDS-DDTF, mDDS-C-var, mDDS-E-var, mDDS-M-var, mPhys-SBI (2nd year)
Additional InformationPresence is obliged at predefined moments of the course (e.g. kick-off
meeting, presentation session, examination) for finishing the course
Custom Course RegistrationPlease register as soon as possible online as there is a maximum number of students that can enter the course.
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. R. Leurs|
|Examiner||prof. dr. R. Leurs|
dr. M.H. Siderius
prof. dr. R. Leurs
dr. J. Kool
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Lecture, Computer lab|
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