Experimental Cell Biology I

2018-2019

Course Objective

The student has insight into and understanding of biological processes
fundamental in living cells.
The student has an overview of techniques used in Cell Biology and
understands their working principle.
The student can work with scientific literature.

Course Content

We start with a brief repetition of basic Cell Biology and then go ahead
with in-depth discussion of modern Cell Biology, with a particular focus
on current and emerging experimental techniques. In Research Lectures,
current topics in Cell Biology will be discussed.

Topics:
• General cell organization and function, protein, DNA and RNA
function, cell cycle and (programmed) cell death
• Transcription factors, gene expression, and epigenetics
• Protein modification, sorting, and membrane transport
• Receptors and signal transduction
• Basic techniques in Cell Biology (PCR, Electrophoresis, ELISA,
• Current models organisms in Cell Biology (e.g. E. coli, yeast, C.
elegans, drosophila, zebra fish, mammalian models)
• Visualization techniques in Cell Biology
Each student will also work on a literature assignment.

Teaching Methods

Lectures (26h), work discussions related to the literature assignment
(6h), self-study in groups to repeat lecture material and for literature
assignment.

Method of Assessment

Written exam (2/3), literature assignment (1/3). Next to a minimum
combined grade of 6.0 for whole course a minimum grade of 5.0 is
required for the written exam and for the literature assignment.

Literature

No book mandatory. Useful books are:
Alberts et al. Molecular Biology of the Cell (more extensive,
recommended for Biomolecular track) or
Alberts et al. Essential Cell Biology (more concise, recommended for
Neurobiology track).
We will also work with scientific literature. Examples: Kuhn Biol.
Chem. 2009, Bald & Koul FEMS Microbiol. Lett. 2010, Galperin et al.
Nucl. Acid Res. 2011.

Additional Information

Compulsory portal course Minor Biomolecular Sciences and Neurosciences.
This minor course requires a minimum of 25 participants to take place.
This course is offered in week 1-4 of period 1 and is to be taken
together with the accompanying course
Experimental Cell Biology II.
This course is based on first and second year level courses
in Cell Biology.

Recommended background knowledge

Basic (first and second year level) courses in Cell Biology

General Information

Course Code AB_1047
Credits 6 EC
Period P1
Course Level 300
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. D. Bald
Examiner dr. D. Bald
Teaching Staff dr. D. Bald
dr. J.M. Kooter
dr. R.J.M. van Spanning
dr. S. Luirink
dr. J.P. van Ulsen
dr. J.R.T. van Weering

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Study Group, Lecture, Practical