Course ObjectiveThe aim of this course is to provide students with insight into the
functioning of the cardiovascular
system, the pathogenesis of the major cardiovascular diseases and in
the possibilities for therapeutic intervention. Pathomechanisms are
discussed that that can lead to the development of myocardial infarction
and heart failure, mechanisms of genetic heart disease and the role of
co-morbidities in cardiac disease.
Course ContentThe course consists of the following subjects:
- Macrocirculation and atherosclerosis
- Microcirculation and vasoregulation
- Heart function and myocardial infarction
- Angiogenesis and arteriogenesis
In the first part of the course, the properties of macrocirculation
(atherosclerosis) and microcirculation (organ level) and their
regulation are discussed, and the changes in the vessel wall that may
lead to increased
blood pressure and atherosclerosis.
In the second part, the heart's action on molecule, cell and
and organ level are discussed, the abnormalities (pathomechanisms) that
arise and different forms of acquired and inherited cardiac disease.
In the third part, the regulation of the barrier function of blood
vessels is discussed and the role of angiogenesis and arteriogenesis.
Teaching MethodsLectures: 18 hours
Practical courses: 6 hours
Workgroups: 10 hours
Method of AssessmentReport of research proposal & presentation: 20%
The two components of the test can be compensated and together they must
LiteratureCardiophysiology concepts, 2nd edition, Richard E Klabunde.
Target AudienceBachelor students Biomed, G&L, GZW, 2nd year or higher.
Additional InformationFor students who will (possibly) choose the Master Cardiovascular
Research, this course is strongly recommended.
Custom Course RegistrationWorkgroups and practicals: see Canvas
Explanation CanvasPractical manuals and study assignments are provided via Canvas
Recommended background knowledgeSufficient and demonstrable knowledge of the physiology and anatomy of
cardiovascular and respiratory system (e.g. Biomed course; Human anatomy
and physiology' or GZW course CRS)
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||J.M. de Winter MA|
|Examiner||prof. dr. J. van der Velden|
dr. P. Koolwijk
dr. E.C. Eringa
prof. dr. J. van der Velden
dr. D.W.D. Kuster
prof. dr. P.L. Hordijk MA
J.M. de Winter MA
R.A. Boon MA
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Seminar, Lecture, Study Group, Practical|
This course is also available as: