Biochemistry in Health and Disease

2019-2020

Course Objective

The aim of the course is to increase knowledge and understanding of
biochemistry at a fundamental level and to develop a perspective on the
role of biochemistry in health and disease.

Course Content

Contents of the course:
* Biochemical and molecular mechanisms by which cellular adhesion,
communication and signalling is regulated in the human body.
* Changes of these mechanisms in diseases with clinical examples of
congenital and acquired diseases such as heart and vascular diseases,
(chronic) infectious diseases, multiple sclerosis, alzheimer disease,
congenital disorders of glycosylation and cancer.
* Metabolic aspects of biochemistry are combined with their application
to
the diagnosis and monitoring of diseases, and the development of
therapies including drug design.

Teaching Methods

Lectures (26-28h), learning in small groups (2h), laboratory course
(4h) and computer practica (8h); in addition, time for self-study is
included in the course.

Method of Assessment

Written exam (90%). Participation in Laboratory course, computer
practicals Glycoworkbench and Drug design (10%)
are mandatory and will be assessed separately. A minimum of 5.50 for the
exam is required in order to pass.

Entry Requirements

Basic knowledge Biochemistry

Literature

- Michael A Lieberman and Alan Marks: Basic Medical Biochemistry: A
Clinical Approach, 4th edition. ISBN: 978-1-45110-003-7.
- Essentials of Glycobiology:
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=glyco2 (free internet
book)
- Additional information & literature provided at the start of the
course on Canvas.

Target Audience

The course provides an excellent basis for students which aim to focus
on medical biology (in particular immunology, infectious diseases and/or
oncology) in their master period.

Additional Information

Lecturers:
dr. R. Fontijn, dr. J.J. Garcia Vallejo, dr.
ing. S.J. van Vliet, dr. J. Haanstra, dr.
E. Struijs, prof. dr. G. Salomons, dr. M. Wamelink,
dr. G. Kooij, prof. dr. J. van Horssen


This course is part of a minor with a limited number of participants.
Students taking the whole minor have priority.

Recommended background knowledge

Basic knowledge Immunology

General Information

Course Code AB_1054
Credits 6 EC
Period P2
Course Level 300
Language of Tuition English
Faculty Faculty of Science
Course Coordinator drs. K. Brouwer
Examiner J.J. Garcia Vallejo BSc
Teaching Staff drs. K. Brouwer
drs. ing. E.A. Struijs
drs. M.M.C. Wamelink
dr. ing. S.J. van Vliet
prof. dr. G.S. Salomons
J.J. Garcia Vallejo BSc

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Computer lab, Study Group, Lecture, Practical