Course Objective-Recognize, interpret and understand the mechanisms contributing to
normal and pathological immune responses;
-Reproducing processes related to the development and functioning of
immune cells which are involved in ‘innate immunity’ and ‘adaptive
-Formulate, calculate and apply immunological methods; recognize and
demonstrate specific immune cells
-Identify disturbed immunological processes in diseases, like cancer,
autoimmunity, infectious diseases, allergy and inflammatory diseases of
-Reproducing molecular processes that are basic to targeted cancer
-Describe applied immunological research and formulate questions on that
-Extract details from the literature; present and discuss these topics
and formulate the essence
A student is able to:
-Describe the difference between the cells involved in immunological
protection after an infection or vaccination;
-Describe basic cellular and molecular concepts involved in the innate
and adaptive immunity (antigen recognition, development of receptors,
complete immune response f.i. in an infection);
-Distinguish humoral and cellular responses that establish antigen
specific immune responses;
-Explain how the lymphoid system (tissues and organs) are involved in
antigen specific immune responses;
-Explain how tolerance (self) and immune response (non self) is achieved
-Distract from an experimental set-up which different celltypes have
different immune function;
-Understand the main literature issues discussed in the studygroups, and
familiarize details on the molecular concepts involved;
-Describe disturbed immunological processes that lead to a various
diseases and how to restore these.
Course Content-The basic course Immunology discusses the innate and adaptive immune
response. Both cellular and molecular interactions that play a
fundamental role in the ‘healthy’ steady-state immune system will be
-The dysregulation of the immune responses that lead to diseases such as
auto-immunity, cancer, chronic inflammatory diseases of the gut, allergy
and infectious diseases will be discussed;
-Lectures, that include details on the immunological immune responses
and research methods are highlighted. Also new applications that lead to
new interventions based on todays research will be discussed (24 h.);
-Studygroups, for which assignments are made in advance using literature
and the given lectures, take place in small groups with a high degree of
individual interaction. A digital educational program is used in the
classroom. The assignment and questions raised will be discussed
together (appr. 4 h.) Working groups themes are : Antigen
presentation/Vaccination and Antibodies
-Digital practical class, in which the structure of lymphoid organs and
immunological and histological techniques are treated (appr. 2 h.);
-In two laboratory classes immunological techniques are studied and
experimentally performed (8 h.): ELISA (4 h.) and Phagocytosis (4 h.)
-A poster presentation during which students make a poster and
present-discus a poster, using literature. There a three themes to
choose (4 h.)
Teaching Methods-Lectures: 24 h.
-Studygroups: 4 h.
-Practical classes: 8 h
-Poster presentation: 4 h.
Method of AssessmentThe exam (90%): digital exam which consists of Multiple Choice-questions
based on the literature, lectures, studygroups, the digital practical
class and experimental practical classes
Poster presentation (10%)
A minimum score of 5.50 for the written exam and the poster presentation
is required in order to pass.
LiteraturePeter Parham, The immune system, 4th edition, Garland Science, New York
and London, 2015. ISBN: 0-8153-4527-5.
Target AudienceCompulsory course 1st year Bsc Biomedical Sciences
Custom Course RegistrationRegistration is only open after passing the course 'Fire-fighting instruction: AB_BMW_BRAND'
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||drs. K. Brouwer|
|Examiner||prof. dr. Y. van Kooyk|
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Study Group*, Lecture, Practical*|
*You cannot select a group yourself for this teaching method, you will be placed in a group.
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