Advanced Molecular Immunology and Cell Biology


Course Objective

To acquire insight into:
• the molecular and cellular aspects of lymphoid organ development
• cellular interactions within the immune system and how molecular
diversity is generated to regulate immune responses.
• the various strategies of host immune responses against pathogens, and
how pathogens escape proper immune responses.
• the various strategies of the host to positively or negatively affect
immune responses during disease (cancer, inflammatory diseases,
• mechanisms by which the immune system regulates either immune
activation or tolerance induction.
• the mechanism of cell migration within the immune system.
• immunodeficiencies and immunometabolism

End terms:
Knowledge: At the end of the course the student is familiar
with current knowledge on the induction and regulation of immune
responses in health and disease.

- The student is capable of applying the acquired knowledge and can
interpret scientific literature and scientific hypotheses of each of the
topics described above.
- The student is able to formulate a scientific hypothesis and can
design a research proposal addressing the hypothesis.
- The student is able to present and discuss the research proposal
with peers.

Course Content

Immunology is a rapid growing field of research in medicine and attracts
a lot of attention for its contribution in various diseases such as
infection diseases, cancer and auto-immunity. The course will give the
student the opportunity to enhance the knowledge on the scientific
aspects within the field of immunology. Special focus lies on the
immunological processes underlying homeostasis control i.e., tolerance
induction, immunity, antigen presentation and processes that lead to the
development of inflammatory diseases (infection diseases through
pathogens), auto-immunity (neuro-immunology) and cancer. Because this
is an advanced course in the field of immunology, and will go into
depth, particular on molecular details, students should be familiar with
basic immunology preferably via a previous basic training course in

Teaching Methods

The course covers immunological processes at the molecular level, and
consists of lectures (H; 22 hours) and study groups (W; 14 hours).

In the study groups students will
read review articles as well as primary scientific articles on the
subjects and discuss in groups opposing views on the molecular
immunological processes that occur in the different stages of
homeostasis and disease control. State of the art will be discussed of
all topics, which will facilitate the study of scientific articles.
Additionally, there is time for self study as well as time to design a
research proposal (pro; 4 hours), which will be presented. The first
weeks include lectures, study groups, self study and preparation and
presentation of the research proposal, whereas the last part mainly
covers self study and the exam.
Contact hours with teachers and/ or coordinators: 40

Method of Assessment

Study groups and active participation are compulsory. A substitution
assignment is required when one or more workshops have not been
attended, or when participation is judged as unsatisfactory.

A written exam (T) at the end of the course includes assay (‘open’) (90%
of grade). A minimum score of 5.50 for the written exam is required in
to pass. The research proposal (Pres) has to be presented and accounts
for 10% of
the grade.

Entry Requirements

Solid knowledge on basic immunology is compulsory before the start of
the course.


Lectures, reviews and scientific papers are part of the material that
covers the exam (posted on Canvas).

Target Audience

Students with a keen interest to study immunological processes that form
a basis for a variety of occurrences of diseases. In particular those
that cover the interaction between host-pathogen, host–tumor and
homeostatic control.
Compulsory course for MSc Biomedical Sciences student with
specialization Immunology, optional course for specialization Infectious

Additional Information

prof. dr. R.E. Mebius, prof. dr. M. van Egmond, prof. dr. H.E. de Vries,
prof. dr. Y. van Kooyk, dr. ing. S.J. van Vliet, dr. J.M.M. den Haan,
prof. dr. S. Nejentsev, dr. J. Van den Bossche

General Information

Course Code AM_470656
Credits 6 EC
Period P1
Course Level 500
Language of Tuition English
Faculty Faculty of Science
Course Coordinator drs. K. Brouwer
Examiner prof. dr. R.E. Mebius
Teaching Staff dr. J.M.M. den Haan
prof. dr. R.E. Mebius
prof. dr. Y. van Kooyk
prof. dr. H.E. de Vries
dr. ing. S.J. van Vliet
prof. dr. M. van Egmond

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Study Group*, Lecture

*You cannot select a group yourself for this teaching method, you will be placed in a group.

Target audiences

This course is also available as: