Course ObjectiveAt the end of this course, the student has detailed knowledge and
understanding of the principles of functional morphology and physiology
of the muscular system embedded within a connective tissue context as
well as of the mechanical load induced adaptations thereof. The student
is able to apply and discuss this knowledge with respect to problems
and questions related to locomotion, movement, training induced muscle
adaptation and orthopeadic interventions.
Course ContentDuring the course, a critical evaluation is made of the current
knowledge of how muscle structure and function are related and how
these properties adapt in response to mechanical loading.
This involves the subjects indicated below:
- force exertion by sarcomeres, muscle fibers, muscle and muscle
- functional morphology and determinants of the muscle length- force-
- heterogeneity in mechanical properties and functional consequences;
- force transmission between muscle fiber, tendon and fascia;
- adaptation of muscle due to growth, immobilization, training and
- mechanotransduction and cellular signaling in the regulation of
adaptation of muscle size.
The course consists of a series of lectures and tutorials. In this
combination, the relevant topics will be addressed, explored and
discussed. One practical is included in which the analysis of gene
expression in muscle in reponse to mechanical loading will be
Method of AssessmentExam
The assessment consists of:
- written examination (essay questions including calculations) - 90%;
- practical report - 10%.
Entry RequirementsThe student should have basic knowledge and understanding of the muscle
anatomy and physiology as well as molecular biology.
LiteratureLecture notes, book chapters, research articles and review papers which
will be made available before the course.
|Language of Tuition||English|
|Faculty||Fac. of Behavioural and Movement Science|
|Course Coordinator||dr. R.T. Jaspers|
|Examiner||dr. R.T. Jaspers|
dr. R.T. Jaspers
You need to register for this course yourself
|Teaching Methods||Seminar, Lecture, Practical|