Tissue Engineering and Mechanobiology


Course Objective

At the end of the course, the student is able to:
• Describe and understand the principles of tissue engineering and
regenerative medicine
• Describe and understand the clues derived from embryogenesis, and
how these may be implemented in tissue engineering and regenerative
• use the knowledge provided in this course to formulate strategies
to translate and clinically implement the principles of tissue
engineering (“from bench to bedside”)

Course Content

This course addresses regenerative medicine, also referred to as
reparative medicine or tissue engineering, which is the regeneration and
remodeling of tissue in vivo in order to repair, replace, maintain or
enhance organ function, as well as to engineer and grow functional
tissue substitutes in vitro for implantation in vivo as biological
substitutes for damaged or diseased tissues and organs. Regenerative
medicine is a multidisciplinary field involving biology, medicine, and
engineering. Regenerative medicine will revolutionize surgical
disciplines, and is expected to become the surgical golden standard of
the upcoming decade by supporting and activating the body’s natural

The course will address:
- the general build-up of organisms (organs, tissues, and their basic
building blocks: the cells and the matrices surrounding them) and the
various modes/levels of communication and organization.
- lessons to be learned from embryogenesis and epimorphic regeneration
(regeneration of entire tissues and organs, e.g. observed in amphibians)
- basics of cell biology and mechanobiology
- the main regenerative medicine building blocks: biomaterials,
biologics (inductive stimuli) and (stem) cells.
- how to “translate” basic regenerative medicine/tissue engineering
principles from fundamental research via translational research towards
clinical implementation (“from bench to bedside”)
- examples of tissue engineering research on the VU campus

Teaching Methods

lectures: 18h
tutorials/presentations/discussions: 14h
Exam: 2.5h

Method of Assessment

Written exam (multiple choice + open questions)


Research articles, lectures (including notes) uploaded on Canvas

General Information

Credits 3 EC
Period P6
Course Level 400
Language of Tuition English
Faculty Fac. of Behavioural and Movement Science
Course Coordinator dr. M.N. Helder
Examiner dr. M.N. Helder
Teaching Staff dr. M.N. Helder

Practical Information

You need to register for this course yourself

Teaching Methods Seminar, Lecture