Course ObjectiveLearning objectives for this course are:
Academic and Research Skills:
- the student is able to conduct a basic statistical analysis for an
- the student is able to coherently report findings from an economic
evaluation in a written report;
- the student is able to critically assess a published economic
- the student is able to design a basic economic evaluation alongside a
randomized controlled trial;
- the student is able to correctly interpret and report the findings
from an economic evaluation alongside a randomized controlled trial;
- the student is able to perform a basic cost-effectiveness analysis
(Incremental Cost-Effectiveness Ratio, bootstrapping, cost-effectiveness
plane, cost-effectiveness acceptability curve) within a structured
Bridging Theory and Practice - Knowledge
- the student is able to explain why economic evaluations are
fundamental for making allocation decisions in health care;
- the student has basic knowledge on the design, analysis,
interpretation and reporting of economic evaluations.
Bridging Theory and Practice - Application
- the student is able to formulate a reimbursement decision based on the
knowledge obtained from an economic evaluation.
Course ContentAt the end of this course, you know the basic essentials of economic
evaluations of health care processes and health care technology. You
will be able to make an informed choice between a trial-based and a
model-based approach. The strengths and limitations of economic
evaluations will be clear. You will be able to design a health economic
evaluation, to critically assess the results of cost-effectiveness
studies conducted alongside a randomized controlled trial, and to
interpret and use information from published economic evaluations.
Teaching MethodsLectures: 12 × 2 hours = 24 hours
Tutorials (including computer practica): 5 × 4 = 20 hours, at least 75%
of the tutorials should be attended by the student.
Method of AssessmentWritten exam: individual assessment, 60% of the final grade, minimum
Assignments: group assessment (groups of two students), 40% of the final
grade, minimum required 5.5, maximum grade resit 6.5
Literature- Goodman CS. HTA 101: Introduction to Health Technology Assessment.
Bethesda, MD: National Library of Medicine (US); 2014 –Chapters I, II,
III, IV, V and X
- Rudmik L, Drummond M. Health economic evaluation: important principles
and methodology. Laryngoscope. 2013 Jun;123(6):1341-7.
- Zilberberg MD, Shorr AF. Understanding cost-effectiveness. Clin
Microbiol Infect. 2010 Dec;16(12):1707-12
- Whitehead SJ, Ali S. Health outcomes in economic evaluation: the QALY
and utilities. Br Med Bull. 2010;96:5-21.
- van den Brink M, van den Hout WB, Stiggelbout AM, Putter H, van de
Velde CJ, Kievit J. Self-reports of health-care utilization: diary or
questionnaire? Int J Technol Assess 11 Health Care. 2005
- Goossens ME, Rutten-van Mölken MP, Vlaeyen JW, van der Linden SM. The
cost diary: a method to measure direct and indirect costs in
cost-effectiveness research. J Clin Epidemiol. 2000 Jul;53(7):688-95.
- Koopmanschap MA, van Exel JN, van den Berg B, Brouwer WB. An overview
of methods and applications to value informal care in economic
evaluations of healthcare. Pharmacoeconomics. 2008;26(4):269-80.
- Krol M, Brouwer W. How to estimate productivity costs in economic
evaluations. Pharmacoeconomics. 2014 Apr;32(4):335-44.
- Thompson SG, Barber JA. How should cost data in pragmatic randomised
trials be analysed? BMJ. 2000 Apr 29;320(7243):1197-200.
- Black WC. The CE plane: a graphic representation of
cost-effectiveness. Med Decis Making. 1990 Jul-Sep;10(3):212-4.
- Barber JA, Thompson SG. Analysis of cost data in randomized trials: an
application of the non-parametric bootstrap. Stat Med. 2000 Dec
- Fenwick E, Marshall DA, Levy AR, Nichol G. Using and interpreting
cost-effectiveness acceptability curves: an example using data from a
trial of management strategies for atrial fibrillation. BMC Health Serv
Res. 2006 Apr 19;6:52.
- Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D,
Augustovski F, Briggs AH, Mauskopf J, Loder E; ISPOR Health Economic
Evaluation Publication Guidelines-CHEERS Good Reporting Practices Task
Force. Consolidated Health Economic Evaluation Reporting Standards
(CHEERS): explanation and elaboration: a report of the ISPOR Health
Economic Evaluation Publication Guidelines Good Reporting Practices Task
Force. Value Health. 2013 Mar-Apr;16(2):231-50.
- Sullivan SD, Mauskopf JA, Augustovski F, Jaime Caro J, Lee KM, Minchin
M, Orlewska E, Penna P, Rodriguez Barrios JM, Shau WY. Budget impact
analysis-principles of good practice: report of the ISPOR 2012 Budget
Impact Analysis Good Practice II Task Force. Value Health. 2014
- Roseboom KJ, van Dongen JM, Tompa E, van Tulder MW, Bosmans JE.
Economic evaluations of health technologies in Dutch healthcare
decision-making: a qualitative study of the current and potential use,
barriers, and facilitators. BMC Health Serv Res. 2017;17(1):89.
- Petrou S, Gray A. Economic evaluation using decision analytical
modelling: design, conduct, analysis, and reporting. BMJ. 2011 Apr
Target AudienceThird year BSc students doing the minor Health Care Management
Recommended background knowledgeNone
|Language of Tuition||English|
|Faculty||School of Business and Economics|
|Course Coordinator||prof. dr. M.W. van Tulder|
|Examiner||prof. dr. M.W. van Tulder|
You need to register for this course yourself
|Teaching Methods||Seminar, Computer lab, Lecture|
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