Tracer Kinetic Modelling


Course Objective

The 6 EC master course Advanced Medical Technology aims to provide the
student knowledge and skills in the field of Tracer Kinetic Modelling.
Starting with the basis of PET-imaging and signal-&-system-analysis the
courses develops to an state-of-the-art discussion of 1) different
tracer-kinetic models and their physiological interpretation, 2)
signal-&-system-analysis based administration (e.g.
bolus infusion & steady state) of radiotracers and radiotracer
concentration measurements, 3) estimation of model parameters using
different least square estimation techniques.

Course Content

This year the course Advanced Medical Technology concerns the topic of
Tracer Kinetic Modelling applied to Analysis of PET studies. To be
short, a PET image visualises the spatial distribution of a
radio-pharmaceutical (or radiotracer i.e., radio-labelled substances)
within the human body. The quantitative analysis of the radiotracer
distribution and its temporal behaviour, using the
TracerKinetic-Modelling approach, enables the interpretation of the PET
studies in terms of physiological processes, such as regional perfusion
of the myocardium and brain, glucose utilisation in tissues and tumors,
and binding of medicines at receptors in the cell membrane. Topics
highly value for clinical diagnostics and, moreover, topics in
state-of-the-art fundamental and clinical research.
Tracer Kinetic Modelling is the field of studying the time course of a
radiotracer and its metabolites in the human body by using quantitative
methods such as: the Positron Emission Tomograph (PET), mathematical
modelling of pharmacokinetics (using differential equations and the
theory of signals & system), estimation of model parameter (using linear
and non-linear least-square techniques) and, finally, the tools
developed for the tracer-kinetic-model-based analysis and the
interpretation and the clinical use of PET-images.

Teaching Methods

The course consists of lectures and hands-on computer practicals with

Method of Assessment

Assignments & written examination.

General Information

Course Code XM_0014
Credits 6 EC
Period P5
Course Level 400
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. ir. M.M. Yaqub
Examiner dr. ir. M.M. Yaqub
Teaching Staff dr. ir. M.M. Yaqub
prof. dr. R. Boellaard

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar, Lecture, Practical
Target audiences

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