Course ObjectiveLecture topics:
• The evolution of drug safety testing and ethical issues related to
• Russell and Burch and the origins and implementation of the 3Rs.
• Cell culture including primary cells, cell lines, and induced
pluripotent Stem Cells (iPSC): generation, culture.
• Toxicity assays, Molecular Toxicology and Systems Biology (omic)
• Regulation, validated alternatives and future aspects.
Course ContentThe course provides an understanding of issues involved in the
development of alternative to animals for hazard and risk assessment of
chemicals. The lectures will cover the 3R principles, i.e. REPLACEMENT,
REFINEMENT AND REDUCTION of Animal use in the life sciences, first
coined by WMS Russel and RL Burch in 1959. Today the 3R principle is a
central part of the Directive 2010/63/EU regulating animal testing and
thus integral part of animal protection law and lab-animal handling in
all EU member states.
Teaching MethodsTeaching will be through lectures and course work.
Method of AssessmentCourse work assessment and exam.
Entry RequirementsThere are no entry requirements.
LiteratureThe Three Rs and the Humanity Criterion: An Abridged Version of the
Principles of Humane Experimental Technique by W.M.S. Russell and R.L.
Burch, Michael Balls
Bal-Price, A., Jennings, P., 2014. In Vitro Toxicology Systems.
Target AudiencemDDS, mCHEM, mBMS and PhD - AIMMs, but others welcome
Recommended background knowledgeThere is no background needed.
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. P. Jennings|
|Examiner||prof. dr. P. Jennings|
prof. dr. P. Jennings
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Lecture, Study Group|
This course is also available as: