Translational Radiopharmaceutical Sciences

2019-2020

Course Objective

To obtain detailed knowledge of translational radiopharmaceutical
sciences

Course Content

Radiopharmaceutical sciences concern the development and evaluation of
radiolabeled compounds, so-called radiopharmaceuticals. These
radiopharmaceuticals can be either imaging agents for Positron Emission
Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)
or therapeutic agents. The stunning clinical successes of nuclear
imaging and targeted radionuclide therapy have resulted in a rapid
growth of the field of radiopharmaceutical sciences, a truly
translational scientific discipline in which design, synthesis and
application of radiopharmaceuticals is key.
This course focusses on radiopharmaceutical design, including target
validation with molecular biology techniques, lead finding and
optimization for radiopharmaceuticals, in vitro investigations,
preclinical research including imaging and metabolism, radiopharmacy
aspects like Good Manufacturing Practice, regulatory matters (eg
Eudralex 4) and European Pharmacopea.

Teaching Methods

The "Flipped classroom method" is used. Lectures have been recorded
(slides + audio) and
need to be independently studied by the students (there are no regular
classes). Rather, all contact hours are used for problem solving
sessions and case studies.

Method of Assessment

Written examination(s)

Entry Requirements

preferably basic knwoledge about organic chemistry, radiopharmaceutical
chemistry

Literature

Radiopharmaceutical Chemistry, Jason S. Lewis, Albert D. Windhorst,
Brian M. Zeglis, editors, Springer, 2019. ISBN 3319989464

Target Audience

mDDS, DD&S

Custom Course Registration

VUNet

Recommended background knowledge

bachelor pharmaceutical sciences, chemistry or alike

General Information

Course Code XM_0067
Credits 6 EC
Period P1
Course Level 400
Language of Tuition English
Faculty Faculty of Science
Course Coordinator prof. dr. A.D. Windhorst
Examiner dr. D.J. Vugts
Teaching Staff dr. D.J. Vugts
prof. dr. A.D. Windhorst

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Lecture, Practical
Target audiences

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