Course ObjectiveGiving a clear description on the instrumental and bio-analytical
techniques and strategies that are used in biomedical and clinical
analysis and diagnostics.
Course ContentThe course will start with discussing the basics of bio-analytical and
clinical chemistry focusing on decision trees (strategic decisions) that
can be used during the method development and optimization of analytical
procedures to determine both endogenous and exogenous compounds in
complex biological samples. Approaches and procedure with respect to
sampling, sample preparation, separation, as well as immunological and
enzymatic procedures will be dealt with. Special attention will be given
to the simultaneous determination of parent compounds in the presence of
their degradation products, metabolites, precursors and/or structure
analogues. In addition to target finding, screening procedures in the
fields of metabolomics, proteomics, etc . will be highlighted. During
the course case studies will be used to clarify the decisions that have
to be taken using advanced bio-analytical and clinical determinations.
Teaching MethodsLectures and tutorials
Method of AssessmentWritten examination
LiteratureM.L. Bishop, E.P. Fody, L.E. Schoeff, Clinical Chemistry, Wolters
Kluwer, Philadelphia, Sixth edition, 2010.
Target AudiencemDDS, mMNS, mCH-AS (however, not in combination with Bio-Analysis &
Additional InformationThis course can not be followed in combination with Bio-Analysis &
Recommended background knowledgeBasic knowledge on analytical chemistry, biochemistry, chromatography,
electrophoresis and mass spectrometry
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||prof. dr. G.W. Somsen|
|Examiner||prof. dr. G.W. Somsen|
prof. dr. G.W. Somsen
You need to register for this course yourself
Last-minute registration is available for this course.
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