Course ObjectiveIntroduction to Systems Biology is the starting course of the
Bioinformatics and Systems Biology master (together with Fundamentals of
- To make the student acquainted with the major approaches and
methodology in systems biology (to be studied in more detail in the
- To develop a basic understanding of biological concepts that are
relevant to current topics in systems biology.
- To gain hands-on experience in basic modelling as a means of solving
systems biology problems.
- To repair gaps in background knowledge.
Course ContentTheoretical topics:
- The two branches of systems biology
- Data structure, geometrical mapping, PCA, distance metrics, clustering
- Cellular composition, diffusion, time scales, rates
- Mass-action, mass balances, reactions, equilibria, stable/unstable
steady states equilibrium binding, affinity, conformational change,
ultrasensitivity, transduction cascades, autoregulation, mutual
inhibition/activation, bistability, feed-forward loops, steady state
metabolism, regulation of metabolism and regulation by demand
- Exercises during/in between lectures in which methods of systems
biology will be applied to several topics.
- Conversion classes
Depending on their background, students will also be assigned to two out
of three deficiency classes where they will be working to fill gaps in
their knowledge in mathematics, programming and/or biology.
Teaching Methods- Lectures (two hour lecture in the morning, two days per week)
- Computer- and modelling practicals
- Conversion classes in biology, mathematics and/or programming
Method of Assessment30% Mathematics, Programming or Biology conversion classes
70% Exam of the Systems Biology subjects
LiteratureA course syllabus will be provided
Target AudienceStudents with a bachelor degree in Biology, Bioinformatics, Mathematics,
Physics or similar background
Recommended background knowledgeMathematics at highschool level
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||dr. D. Molenaar|
|Examiner||dr. D. Molenaar|
dr. D. Molenaar
prof. dr. B. Teusink
prof. dr. F.J. Bruggeman
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Seminar, Lecture, Study Group|
This course is also available as: