Principles of Systems Biology


Course Objective

This course aims to give a broad overview over topics related to Systems
Biology. In addition it intends to fill gaps in your background
knowledge to ensure you can take more advanced systems biology courses.

Course Content

Theoretical topics:
- The two branches of systems biology
- Data structure, geometrical mapping, PCA, distance metrics, clustering
- Cellular composition, diffusion, time scales, rates
- Mass-action, mass balances, reactions, equilibria, stable/unstable
steady states equilibrium binding, affinity, conformational change,
ultrasensitivity, transduction cascades, autoregulation, mutual
inhibition/activation, bistability, feed-forward loops, steady state
metabolism, regulation of metabolism and regulation by demand

- Exercises during/in between lectures in which methods of systems
biology will be applied to several topics.

- Conversion classes
Depending on their background, students will also be assigned to one out
of three deficiency classes where they will be working to fill gaps in
their knowledge in mathematics, programming and/or biology.

Teaching Methods

- Lectures (two hour lecture in the morning, two days per week)
- Computer- and modelling practicals

Method of Assessment

Exam of the Systems Biology subjects

Target Audience

This course may only be followed by students enrolled in the BSc minor
Bioinformatics and Systems Biology.

General Information

Course Code X_428566
Credits 6 EC
Period P1
Course Level 300
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. D. Molenaar
Examiner dr. D. Molenaar
Teaching Staff dr. D. Molenaar

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar, Lecture, Computer lab
Target audiences

This course is also available as: