Structure Biology

2019-2020

Course Objective

Obtaining insight into the molecular elements that form the basics for
structure and function of biomolecules. Also, gaining of knowledge about
the methods used to determine the structure and analyze the function of
proteins.

Course Content

Central to this course are molecular properties of structural elements
of DNA, lipids and proteins. The forces and interactions that determine
their structure, function and flexibility will be discussed. The basics
and applications of a number of techniques used to experimentally
determine macromolecular structures as well as techniques to visualize
dynamic structural changes will also be introduced. This includes
crystallization followed by X-ray diffraction, NMR spectroscopy and
electron microscopy. Also, the principles and applications of
computational structure determination (protein modeling) will be
discussed.

Teaching Methods

Lectures, self-study, assignments.

Method of Assessment

Written Exam

Literature

Branden, C., and Tooze, J., Introduction to Protein Structure, Garland,
1999.

Target Audience

3F,3S, mi-AMPS

Additional Information

For PyMOL exercieses install PyMOL Educational Version (limited to the
use within this course!) and bring a three button
computer mouse as a touchpad will not be sufficient.

Explanation Canvas

Lecture material as well as additional material will be published in
CANVAS.

Recommended background knowledge

Project Cancer (MNW), Biochemistry Course (S/F/MNW).

General Information

Course Code X_430080
Credits 6 EC
Period P5
Course Level 300
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. S. Hennig
Examiner dr. S. Hennig
Teaching Staff dr. S. Hennig
dr. D.P. Geerke

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar, Lecture, Excursion
Target audiences

This course is also available as: