Course ObjectiveTo gain knowledge of the most important theoretical and practical
concepts in modelling and simulation of biomedical processes at
different scales, ranging from macroscopic organ function, cellular
function down to biochemical interactions and signaling pathways within
To gain experience with and to apply MatLab and Mathematica to acquire,
analyse and evaluate biomedical signals and to model and simulate
Course ContentThis course will start with a general overview the various types of
models used to describe biomedical processes by parametric and
non-parametric models using linear and non linear (differential)
equations. Basic knowledge of vector and matrix calculations and
differential equations is required but will be refreshed.
During the course, attention will be paid to viscoelastic models,
spectral analysis, compartment models, geometric modelling used in image
analysis and models to describe molecular structures and their dynamic
Examples will concentrate on cardiovascular function: linear and
viscoelastic models of pressure volume relations, compartment models of
the interaction between contractile proteins to simulate force and
pressure development and a description of an ion pump for instance to
import Ca-ions into the cell during an action potential.
The introductory lectures will be combined and followed by practical
courses in which, through exercises, experience will be gained of
MatLab and Mathematica (4th generation computer languages). Finally
students will be offered a choice of 1 out of 5 modelling problems to
be solved in small groups, guided by a supervisor. At
the end of the course each group will present and discuss their work
with all participants and supervisors of the course.
Teaching MethodsLectures, working groups, assignments.
Method of AssessmentAssignments (20%), report and presentation on modelling problem (40%)
and written exam (40%).
Book (recommended): Gilat, A., MatLab: An Introduction with
Applications, 5th ed, Wiley.
Target AudiencemCh-SBI, mMNS-MPs, mMNS-PoL, mMNS-MPy, mPhys-BB, mPhys-SBI
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||dr. I.H.M. van Stokkum|
|Examiner||dr. I.H.M. van Stokkum|
dr. ir. T.J.C. Faes
dr. I.H.M. van Stokkum
You need to register for this course yourself
Last-minute registration is available for this course.
|Teaching Methods||Seminar, Lecture, Study Group, Practical|
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