Biomedical Modelling and Simulation


Course Objective

To gain knowledge of the most important theoretical and practical
concepts in modelling and simulation of biomedical processes at
different scales, ranging from macroscopic organ function, cellular
function down to biochemical interactions and signaling pathways within

To gain experience with and to apply MatLab and Mathematica to acquire,
analyse and evaluate biomedical signals and to model and simulate
biomedical processes.

Course Content

This course will start with a general overview the various types of
models used to describe biomedical processes by parametric and
non-parametric models using linear and non linear (differential)
equations. Basic knowledge of vector and matrix calculations and
differential equations is required but will be refreshed.

During the course, attention will be paid to viscoelastic models,
spectral analysis, compartment models, geometric modelling used in image
analysis and models to describe molecular structures and their dynamic

Examples will concentrate on cardiovascular function: linear and
viscoelastic models of pressure volume relations, compartment models of
the interaction between contractile proteins to simulate force and
pressure development and a description of an ion pump for instance to
import Ca-ions into the cell during an action potential.

The introductory lectures will be combined and followed by practical
courses in which, through exercises, experience will be gained of
MatLab and Mathematica (4th generation computer languages). Finally
students will be offered a choice of 1 out of 5 modelling problems to
be solved in small groups, guided by a supervisor. At
the end of the course each group will present and discuss their work
with all participants and supervisors of the course.

Teaching Methods

Lectures, working groups, assignments.

Method of Assessment

Assignments (20%), report and presentation on modelling problem (40%)
and written exam (40%).


Book (recommended): Gilat, A., MatLab: An Introduction with
Applications, 5th ed, Wiley.

Target Audience

mCh-SBI, mMNS-MPs, mMNS-PoL, mMNS-MPy, mPhys-BB, mPhys-SBI

General Information

Course Code X_430112
Credits 6 EC
Period P1
Course Level 400
Language of Tuition English
Faculty Faculty of Science
Course Coordinator dr. I.H.M. van Stokkum
Examiner dr. I.H.M. van Stokkum
Teaching Staff dr. ir. T.J.C. Faes
dr. I.H.M. van Stokkum

Practical Information

You need to register for this course yourself

Last-minute registration is available for this course.

Teaching Methods Seminar, Lecture, Study Group, Practical
Target audiences

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