General Information
Course Code | X_432536 |
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Credits | 6 EC |
Period | P2 |
Course Level | 500 |
Language of Tuition | English |
Faculty | Faculty of Science |
Course Coordinator | dr. J.N.M. Commandeur |
Examiner | dr. J.N.M. Commandeur |
Teaching Staff |
prof. dr. P. Jennings dr. J.N.M. Commandeur dr. ir. J.C. Vos dr. A. Wilmes |
Practical Information
You need to register for this course yourself
Last-minute registration is available for this course.
Teaching Methods | Lecture |
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Target audiences
This course is also available as:
Course Objective
At the end of this theoretical course, the students are aware of thelatest insights of cellular stress responses which can occur after
exposure of cells to reactive drugs and/or reactive drug metabolites.
Course Content
Exposure of tissues to high levels of drugs and/or drug metabolites insome cases can trigger various biochemical responses. Interaction with
sensor proteins can lead to adaptative stress responses which will
protect the cell against further damage. If these adaptative stress
responses are insufficient, interaction with critical proteins may lead
to cell death or exaggerated, fatal pharmacological responses.
The following aspects will be studied in the course drug-induced stress
and cellular signaling:
• (types of) adverse drug reactions
• role of biotransformation and drug transport in adverse drug
reactions,
• reversible and irreversible interactions of toxic drugs with
biological macromolecules,
• cellular adaptation to exposure to reactive chemicals and reactive
oxygen species;
• cellular and molecular mechanisms leading to toxic effects,
• role of mitochondria in necrosis and apoptosis,
• immune-mediated toxicity.
• advantages and disadvantages of different (novel) in vitro models used
in toxicity studies.
• cellular parameters reflecting stress-responses and mitochondrial
effects
Teaching Methods
Lectures, assignment and self study.Method of Assessment
Written exam and assignmentEntry Requirements
Bachelor Pharmaceutical Sciences, Biomedical Sciences , Medical NaturalSciences, Medical Biology or equivalent
Literature
Boelsterli, Mechanistic Toxicology: The Molecular Basis of How ChemicalsDisrupt Biological Targets 2nd ed, CRC Press, 2007 (ISBN 0849372720).
Recent literature will be provided