Course ObjectiveTo obtain a general introduction into and deepening of knowledge of
fundamental principles and molecular aspects of drug action within the
field of molecular pharmacology and receptor biochemistry.
Course ContentMost drugs display their pharmacological actions following the
interactions with receptor proteins. As for the molecular
pharmacological aspects the mechanisms by which these drugs act with
respect to their therapeutic application will be studied. Novel concepts
of pharmacology, including constitutive receptor activity, allosteric
modulation, receptor dimerization and ligand-biased signaling will be
addressed. Important cellular and animal model systems used to
investigate (pathological and pharmacological) aspects of cell biology
in relation to drug discovery will be discussed.
Teaching MethodsLectures, exercises, case-studies
Method of AssessmentWritten examination(s) and assignments.
LiteraturePharmacology in Drug Discovery and Development 2nd edition - T.P.
eBook ISBN: 9780128037539
Paperback ISBN: 9780128037522
Scientific papers (primary and review) provided during the course
Recommended background knowledgeKnowledge of basic principles of drug action and mathematics (i.e.
re-arranging formulas and understanding of (non)linear equations).
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||dr. H.F. Vischer|
|Examiner||dr. H.F. Vischer|
dr. H.F. Vischer
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