Course ObjectiveTo obtain detailed knowledge of vital organic reactions and synthetic
Course ContentWithin a medicinal chemistry context, organic synthesis continues to
play a vital role because it allows perceived organic molecules to
actually be prepared. A medicinal chemist with thorough knowledge of the
synthetic toolbox will be able to efficiently find his/her way to a
First, a brief recap of some synthesis principles is offered. Then, the
course will focus on the most important and generally used synthetic
reactions. These include reactions of nucleophilic carbon intermediates,
nucleophilic substitutions, electrophilic additions to carbon-carbon
multiple bonds, reductions, oxidations, cycloadditions, aromatic
substitution reactions, rearrangements, and reactions of transition
metals as well as of Group I and II metals. Collectively, this course
delivers the synthetic knowledge necessary for efficient synthesis of
Teaching MethodsThe "Flipped classroom method" is used.
This means that all lectures have been recorded (slides + audio) and
need to be independently studied by the students (there are no regular
classes). Rather, all contact hours are used for intensive problem
Method of AssessmentTwo written examinations.
Entry RequirementsBasic knowledge of organic chemistry.
LiteratureCarey, F.A., Sundberg, R.J., Advanced Organic Chemistry, Part B, 5th
Target AudiencemDDS, DD&S
Custom Course RegistrationVUNet
|Language of Tuition||English|
|Faculty||Faculty of Science|
|Course Coordinator||dr. M. Wijtmans|
|Examiner||dr. M. Wijtmans|
dr. M. Wijtmans
prof. dr. I.J.P. de Esch
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