Cardiovascular Research Challenges

2018-2019
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Students are required to:
● obtain an up-to-date knowledge of current cardiovascular patient
problems;
● obtain knowledge on current research challenges: methodologies,
funding, communication, sex differences
● learn how to interpret research papers
● learn how to design and present a research proposal

Inhoud vak

Cardiovascular failure is the most common cause of hospitalization in
Western societies and, despite advances in treatments, the prognosis of
patients with heart failure remains poor. Progressive deterioration in
vascular and myocardial function is a crucial feature of chronic heart
failure and is the result of many different pathological processes
affecting the vessels and muscle of the heart. As a result of changes in
lifestyle–leading to obesity, hypertension, and diabetes–cardiac and
vascular problems now frequently arise at a relatively young age. As
life expectancy has increased, this aging population has become
characterized by chronic cardiovascular disease, causing reduced quality
of life and increased healthcare costs. This module examines some of the
current challenges within cardiovascular research.
General aim
While acute and chronic dysfunction of the heart may ultimately cause
heart failure, defects of the lungs and kidney are highly associated
with cardiac failure and death. The Cardiovascular Research Challenges
minor focuses both on the pathology of the heart (e.g., congenital and
inherited cardiomyopathy, ischemic heart disease) and on the interaction
between cardiovascular, pulmonary and renal function. Sexual differences
in cardiovascular disease are highlighted, and recent advances in
therapeutic strategies and newly identified drug targets in the
prevention and treatment of cardiovascular disease are discussed.
Courses:
Course 1. Obesity, diabetes, and heart failure; congenital and inherited
cardiomyopathies
Course 2. Atherosclerosis and coronary artery disease: diagnosis,
treatment, and research
Course 3. Interaction of the lungs, heart, and kidneys

Topic list
● Heart failure and arrhythmia
● Difference in HFpEF and HFrEF
● Diabetes and vascular problems
● Diabetic cardiomyopathy
● Inherited cardiomyopathy
● Causes of arrhythmia
● Cellular mechanisms of heart failure
● Functional imaging of heart diseases by PET/MRI and Echo
● Atherosclerosis and CAD: cellular, functional and clinical
consequences (in the heart and brain)
● Endothelial function and angiogenesis
● Use of animal models in CV research
● Interaction between heart and lungs in PAH, exercise and mechanical
ventilation
● Interaction between kidneys and heart in dialysis and exercise
Skills to be taught over the program:
- search for and source scholarly articles on specific cardiovascular
diseases
- develop comprehension and engage in scientific discussion of academic
articles
- write a research proposal for new research into cardiovascular
disease, applying the concept of the pressure-volume relationship of the
heart to normal and failing hearts
- learn study measurement techniques for basic cardiovascular functions
in humans and animals

Onderwijsvorm

Lectures, practicals, working groups

Toetsvorm

Course 1: Obesity, diabetes and heart failure; congenital and inherited
cardiomyopathies
1. Presentation by the student of a published cardiovascular journal
article and of possible research questions, on a topic assigned by the
teachers (20%).
2. Open question written examination of the subjects in the topic list
(2 hrs ((80%)).

Course 2: Atherosclerosis and coronary artery disease: diagnosis,
treatment, and research
1. Oral presentation of research idea with possible measurements and
background, on a topic assigned by the teacher (20%).
2. Open question written examination (2 hrs ((80%)).

Course 3: Interaction of the lungs, heart, and kidneys
1. Written research proposal in a predefined format on a research
question chosen by the student (80%).
2. Oral presentations of own research proposal and assignments set by
teachers (20%).

Reassessment: If the overall course result is below 6.0 (with a minimum
result of 5.5 in written examination components), the full course
(written and oral parts) will be reassessed by an oral examination,
testing knowledge and understanding of the topics of the course. This
re-examination will be scheduled in the last week of the following
course.

Vereiste voorkennis

Basic knowledge of Heart and Circulation, Physiology and anatomy
Course reading
An overview of the study material is placed on CANVAS, mostly scientific
articles on the subjects discussed.
Target audience
Bachelor students of VUmc School of Medical Sciences and (international)
students, with a biomedical background .
CANVAS
This course is supported by a corresponding CANVAS course, which
contains all of the required information of this course including
overview of the required articles and assignments. The CANVAS course
will also be used to post announcements relevant to the course. You will
automatically have access to the CANVAS course.
Register
All students who enrolled into the International Minor in Medical
Sciences are registered by the IOO for educational activities for this
course and exams.If you want to re-take an exam, you will need to apply
in time for the exam through the form Re-take exam Bachelor of Medicine.

Literatuur

An overview of the study material is placed on CANVAS, consisting
primarily of scientific articles on the subjects discussed.

Doelgroep

Bachelor students of VUmc School of Medical Sciences and (international)
students, with a biomedical background.

Overige informatie

Coordinator:
Prof dr. J. van der Velden and Dr. I. Vergroesen
Examinator:
Prof dr. J. van der Velden

Afwijkende intekenprocedure

Before the start of the semester, students will be invited to select their preferred minor track. However, the Institute of Education and Training (IET) will make a final selection based on both student preferences and availability in the different tracks. Once you have been selected for a track, the IET will make sure you’re registered for all educational activities such as study groups, courses, and exams. Important: Please be aware that in the case that you do not pass an exam, you will NOT be automatically registered for a re-examination, and will need to do this yourself. In order to sign up to resit an examination, you will need to apply no later than 2 weeks before the re-examination through the form “Re-take Exam Bachelor of Medicine.” .

Toelichting Canvas

This course is supported by a corresponding CANVAS course, which
contains all of the required information of this course including an
overview of the required articles and assignments. The CANVAS course
will also be used to post announcements relevant to the course. You will
automatically have access to the CANVAS course.

Aanbevolen voorkennis

Basic knowledge of Heart and Circulation, Physiology and anatomy

Algemene informatie

Vakcode M_BCVRC16
Studiepunten 18 EC
Periode Semester 1
Vakniveau 300
Onderwijstaal Engels
Faculteit VUmc
Vakcoördinator prof. dr. J. van der Velden
Examinator prof. dr. J. van der Velden
Docenten

Praktische informatie

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Werkvormen Hoorcollege, Studiegroep, Practicum