Synthetic Approaches in Medicinal Chemistry

2018-2019
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

To obtain detailed knowledge of vital organic reactions and synthetic
strategies.

Inhoud vak

Within a medicinal chemistry context, organic synthesis continues to
play a vital role because it allows perceived organic molecules to
actually be prepared. A medicinal chemist with thorough knowledge of the
synthetic toolbox will be able to efficiently find his/her way to a
target molecule.
First, a brief recap of some synthesis principles is offered. Then, the
course will focus on the most important and generally used synthetic
reactions. These include reactions of nucleophilic carbon intermediates,
nucleophilic substitutions, electrophilic additions to carbon-carbon
multiple bonds, reductions, oxidations, cycloadditions, aromatic
substitution reactions, rearrangements, and reactions of transition
metals as well as of Group I and II metals. Collectively, this course
delivers the synthetic knowledge necessary for efficient synthesis of
organic molecules.

Onderwijsvorm

The "Flipped classroom method" is used.

This means that all lectures have been recorded (slides + audio) and
need to be independently studied by the students (there are no regular
classes). Rather, all contact hours are used for intensive problem
solving sessions.

Toetsvorm

Written examination(s).

Vereiste voorkennis

Basic knowledge of organic chemistry.

Literatuur

Carey, F.A., Sundberg, R.J., Advanced Organic Chemistry, Part B, 5th
edition.

Doelgroep

mDDS, DD&S

Afwijkende intekenprocedure

VUNet

Algemene informatie

Vakcode X_435685
Studiepunten 6 EC
Periode P2
Vakniveau 500
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. M. Wijtmans
Examinator dr. M. Wijtmans
Docenten dr. M. Wijtmans
prof. dr. I.J.P. de Esch

Praktische informatie

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