Pathophysiology of Heart and Circulatory System

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

The aim of this course is to provide students with insight into the
functioning of the cardiovascular
system, the pathogenesis of the major cardiovascular diseases and in
the possibilities for therapeutic intervention. Pathomechanisms are
discussed that that can lead to the development of myocardial infarction
and heart failure, mechanisms of genetic heart disease and the role of
co-morbidities in cardiac disease.

Inhoud vak

The course consists of the following subjects:
- Macrocirculation and atherosclerosis
- Microcirculation and vasoregulation
- Heart function and myocardial infarction
- Cardiomyopathies
- Angiogenesis and arteriogenesis

In the first part of the course, the properties of macrocirculation
(atherosclerosis) and microcirculation (organ level) and their
regulation are discussed, and the changes in the vessel wall that may
lead to increased
blood pressure and atherosclerosis.
In the second part, the heart's action on molecule, cell and
and organ level are discussed, the abnormalities (pathomechanisms) that
arise and different forms of acquired and inherited cardiac disease.
In the third part, the regulation of the barrier function of blood
vessels is discussed and the role of angiogenesis and arteriogenesis.


Lectures: 18 hours
Practical courses: 6 hours
Workgroups: 10 hours


Report of research proposal & presentation: 20%
Exam: 80%

The two components of the test can be compensated and together they must
be sufficient.


Cardiophysiology concepts, 2nd edition, Richard E Klabunde.


Bachelor students Biomed, G&L, GZW, 2nd year or higher.

Overige informatie

For students who will (possibly) choose the Master Cardiovascular
Research, this course is strongly recommended.

Afwijkende intekenprocedure

Workgroups and practicals: see Canvas

Toelichting Canvas

Practical manuals and study assignments are provided via Canvas

Aanbevolen voorkennis

Sufficient and demonstrable knowledge of the physiology and anatomy of
cardiovascular and respiratory system (e.g. Biomed course; Human anatomy
and physiology' or GZW course CRS)

Algemene informatie

Vakcode AB_1015
Studiepunten 6 EC
Periode P5
Vakniveau 200
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator J.M. de Winter MA
Examinator prof. dr. J. van der Velden
Docenten dr. P. Koolwijk
dr. E.C. Eringa
prof. dr. J. van der Velden
dr. D.W.D. Kuster
prof. dr. P.L. Hordijk MA
J.M. de Winter MA
R.A. Boon MA

Praktische informatie

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Werkvormen Werkcollege, Hoorcollege, Werkgroep, Practicum

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