Genetics and Public Health

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

1. The student can explain that some disorders develop according to
Mendelian principles of inheritance (and knows exceptions to Mendel's
laws), but that genetics plays a different role in many disorders that
are important to public health (such as cancer, cardiovascular
disorders, diabetes mellitus);
2. The student can describe how and where in the health care setting
genetics/genomics is used (clinical genetics, public health, genetic
screening, preconception care). Also, he/she can describe the different
goals of public health versus clinical genetics, and the ethical
dilemmas this raises;
3. The student can explain that tailored prevention is of clinical
benefit, in particular when there is interaction between gene(s) and
4. The student can explain how knowledge of genetics/genomics can be
implemented in health care and what challenges can be expected.

Inhoud vak

Different topics that will be addressed:
• (Beyond) Mendelian inheritance, population genetics, gene-environment
interactions, epigenetics;
• The spectrum of genetic disorders and the relation to health care
(clinical genetics, genetic screening, preconception and prenatal care);
• The impact of a hereditary disease on individuals, families and
• The tension between public health and clinical genetics;
• Genetic risk, psychological and behavioral aspects of genetics;
• Ethical, legal, historical (eugenics) and social aspects of genetics;
• Challenges in the translation of science (new genetic knowledge) into
public policy and healthcare;
• Criteria for (useful) genetic testing, genetic screening, and
direct-to-consumer genetic testing;
• Challenges regarding whole exome and whole genome sequencing;
• New possibilities in personalized medicine using pharmacogenomics;
• New developments regarding gene editing and (ethical) dilemma's.


• (Working) Lectures (30 hrs);
• Subgroup sessions; Discussions in small groups about topical themes
with regard to public health and genetics (6 hrs), and oral
presentations by students (6 hrs);
• Individual assignments and group assignment in which the students work
together describing the translation of a particular genomics application
into healthcare (self-/group study).


Written examination in English consisting of open and multiple choice
questions, based on the lectures and the provided literature (70%), a
written report (20%), and an oral presentation (10%).
Examination, Report, and Presentation should all three be passed (grade
5.5 or more).
Students can only pass if they meet the presence requirements.


A course reader will be available online; additional literature
(articles) will be announced on Canvas shortly before the course


This is a course in the Health Sciences minor Biomedical Topics in
Healthcare. The course is open to both Health Sciences students and
Biomedical students from VU University Amsterdam. Students from other
universities and doing a similar educational track are also invited to
participate. The minor is not recommended for VU Health and Life
Sciences students. We have a maximum of 65 students.

Overige informatie

Course coördinator:
dr. L. Henneman, Dept of Clinical Genetics, Amsterdam UMC, VUMC
Other teachers in this course are:
prof. M.C. Cornel, Dept of Clinical Genetics, Amsterdam UMC, VUMC
dr. C.G. Van El, Dept of Clinical Genetics, Amsterdam UMC, VUMC

Among the guest lecturers are:
prof.dr. M. Mannens, Dept of Clinical Genetics, Amsterdam UMC, AMC
dr. T. Rigter, Dept of Clinical Genetics, Amsterdam UMC, VUMC
dr. Q. Waisfisz, Dept of Clinical Genetics, Amsterdam UMC, VUMC
dr. P. Zwijnenburg, Dept of Clinical Genetics, Amsterdam UMC, VUMC

[Dit vak is onderdeel van een minor en heeft een maximaal aantal
deelnemers. Studenten die de hele minor doen, hebben voorrang.]

Afwijkende intekenprocedure

Aanbevolen voorkennis

Basic genetics

Algemene informatie

Vakcode AB_1025
Studiepunten 6 EC
Periode P2
Vakniveau 300
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. L. Henneman
Examinator dr. L. Henneman
Docenten dr. L. Henneman
dr. C.G. van El
prof. dr. M.C. Cornel

Praktische informatie

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