Human Neurophysiology

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

The overall aim of the course is twofold. Firstly, to provide a
theoretical understanding and hands-on practical experience with
Cognitive Neuroscience research in humans and, secondly, to develop
generic and important academic skills.
In terms of Cognitive Neuroscience, you should at the end of the course
be able to:
1. Explain how human neurophysiology can be investigated and explain the
relative strengths and weaknesses of different neuroimaging techniques.
2. Argue why it is important to perform neurophysiological research on
both healthy people and patients.
3. Differentiate between exogenous (stimulus-driven) and endogenous
(spontaneous) brain activity, and experimental paradigms and analysis
tools required for their study.
4. Argue why the phenomenon of ‘daydreaming’ and its neuronal basis is
important to investigate. In addition, you should have acquired the
skills to perform research on this relationship.
5. Explain the relationship between brain activity and EEG signals.
6. Explain how to prepare a subject for an EEG measurement and
understand acquisition settings such as sampling frequency, filters,
impedance, etc.
7. Use MATLAB-based software for qualitative analysis of EEG, e.g., to
differentiate between EEG signals that originate from muscle and brain
activity, respectively.
8. Perform quantitative and statistical analysis of own data and use the
results to make conclusions about the relation between brain activity
and cognition.
9. Provide an overview of the possibilities and challenges for applying
EEG technology (1) in the diagnosis and therapy of disorders such as
epilepsy, attention disorders, or dementia, and (2) for controlling
machines or computers with your thoughts.

Academic skills to be developed are to:
1. Search for and read scientific literature.
2. Formulate and present a creative research idea.
3. Record, analyze and present data in scientifically efficient and
esthetically appealing figures.
4. Work in groups of 4–5 students.
5. Give constructive feedback on the ideas of fellow students.
6. Summarize your research on a poster and present and defend their

Inhoud vak

The course aims to provide you with theoretical knowledge of how the
human brain and cognition can be studied with current
techniques. In addition, an important component of the course is to
teach you how to perform recordings on normal human subjects using
high-density electroencephalography (EEG) and relate the electrical
signal of the brain to cognition. The emphasis is on non-sensory
cognitive experiences such as "daydreaming". Through a competition early
in the course, students agree on an experimental paradigm in which this
type of cognition can be influenced and you will record, analyze and
present both data on EEG and cognition at the end of the course. The
importance of non-stimulus driven brain activity and cognition for
brain-related disorders such as depression, dementia, insomnia, autism,
attention deficit and hyperarousal disorder (ADHD) is discussed.


Lectures, lab and computer practical, plenary discussions, and
presentations. Attendance is obligatory for all scheduled activities,
except the lectures (although strongly recommended to attend these)

Activity (approximate number of study hours)
Lectures (16)
Reading (35)
Lab experiments (4)
Data analysis in computer rooms (30)
Group discussions (16)
Plenary discussions (8)
Poster preparation (24)
Preparation for exam (35)


• Tentamen:
 Vragen: combinatie open en gesloten
 Afname: schriftelijk

• Weging toetsonderdelen:
 Written exam: 50%
 Content and layout of poster: 16%
 Group presentation of PowerPoint: 10%
 Individual presentation of poster: 24%

• Compensatie:
 Er is geen compensatiemogelijkheid tussen de verschillende

• Herkansing opdrachten:
 Bij hertentamen moment

• Leerlijn Academische Vaardigheden (ACVA):
 Academische houding (kritisch denken, oordeelsvorming en reflectie op
handelen): interpretatie van analyse van eigen data, posteropdracht, en
feedback geven op research proposal en posters van medestudenten
 Informatievaardigheden: dataverzameling in EEG practica en
interpreteren van significante effecten (formatief)
 Schrijfvaardigheden: research proposal en poster maken (summatief)
 Presentatievaardigheden: PowerPoint presentatie van onderzoeksplan en
presentatie van poster (summatief)
 Samenwerken: samenwerken met 3-4 medestudenten aan onderzoeksidee,
onderzoeksplan en poster van onderzoek (formatief)
 Klinisch redeneren: eventuele resultaten in gezonde personen bespreken
in de context van ziektebeelden (formatief)

• Leerlijn Onderzoeksmethoden en Statistiek:
 Onderzoeksmethoden theorie: het leren beantwoorden van een
onderzoeksvraag met experimentele gegevens (in voorbereiding op het
practicum project) (formatief)
 Onderzoeksmethoden praktijk: zelf een onderzoeksvraag bedenken voor de
schrijfopdracht (research proposal) en uitvoeren van analyse voor poster
project (summatief)
 Statistiek theorie: colleges (formatief)
 Statistiek praktijk: dataverzameling, analyse in computer practicum en
posteropdracht (summatief)

• Leerlijn International Science Communication:
 Engels lezen: Engels studiemateriaal (formatief)
 Engels schrijven: onderzoeksplan en poster is in het Engels
 Engels spreken: presentaties van onderzoeksplan en poster is in het
Engels (summatief)


PowerPoints with supporting text below the slides and a reader authored
by the coordinator.

In addition, the following background or scientific articles are used:
• Raichle M. 2010. The brain's dark energy. Scientific American Magazine
• Killingsworth, M. A., Gilbert, D. T. 2010. A Wandering Mind Is an
Unhappy Mind. Science, 330:932.
• Diaz et al., (2014) The ARSQ 2.0 reveals age and personality effects
on mind-wandering experiences. Front Psychol 5:1–8


BSc Gezondheid en Leven jaar 2 en 3
Major Biomedische Wetenschappen (BMW) en major Klinische Wetenschappen

Second/third year Bio-medische Wetenschappen or Biologie.

Overige informatie

This course is recommended for students wishing to do their internship
at CNCR. This course is recommended for students wishing to follow the
Research Master of Neurosciences.

Maximum number of participants: 130

Toelichting Canvas

Canvas is used extensively for tutorials, lecture PowerPoints and for
posting videos of the lectures

Algemene informatie

Vakcode AB_1111
Studiepunten 6 EC
Periode P6
Vakniveau 300
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. K. Linkenkaer Hansen
Examinator dr. K. Linkenkaer Hansen

Praktische informatie

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Werkvormen Hoorcollege, Werkgroep, Computerpracticum, Practicum