Clinical neurosciences

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

The aim of this course is twofold:
1) Provide knowledge on neurological and neuropsychiatric disorders.
2) initiate a translational way of thinking as a neuroscientist.

This course will provide the latest clinical and neurobiological
knowledge on a number of key brain disorders:
Multiple Sclerosis, Childhood White Matter Disorders, Dementia, Movement
Disorders, Neuropsychiatric Disorders and Brain Tumors.
It also introduces some of the tools clinical neuroscientist have at
their disposal to investigate the pathophysiology of brain disorders in
vivo, such as neuroimaging.
This course will stimulate translational thinking by continuously
investigating and crosslinking the (histo)pathology, clinical and
imaging abnormalities for diagnosis and prognosis and therapeutic
Lectures are provided by both researchers AND clinicians to promote
translational thinking.

Inhoud vak

The course evolves around the following brain disorders and diseases:
Multiple sclerosis, Childhood white matter disorders, Dementias,
Movement disorders,
Neuropsychiatric disorders and brain tumors.

Multiple sclerosis:
Description of the clinical phenotypes of the disease. Introduction of
neuroimaging specifically adapted for MS. The use of neuropathology to
understand disease mechanisms in MS.

Childhood white matter disorders:
Introduction to the main clinical manifestations and different forms of
Demonstration of translational research: from patient to
gene, protein and treatment.

Description of the main clinical manifestations of dementia.
Introduction of cognitive assessment in dementias. Demonstration of the
neuropathological features of dementias.

Movement disorders:
Description of the motor and cognitive manifestations of movements
disorders and their underlying neurobiology. The focus will be on
Parkinson’s disease.

Neuropsychiatric disorders:
Description of the clinical manifestation of some of the main
disorders, such as obsessive-compulsive disorder, major depressive
disorder, and post-traumatic stress disorder. Introduction of the
underlying neuroanatomy and pathophysiology and
the role of neuroimaging in neuropsychiatry.

Description of the clinical/cognitive manifestations of brain tumors,
mainly glioma. The effects of these tumors on brain networks is the main


Lectures, student presentations, practical
The course runs for eight weeks, on Mondays and Thursdays


- Group presentation on recent cutting-edge paper on clinical
neuroscience (10% of grade)
- Written essay, in the form of an introduction of a research paper
- Two written interim exams with open questions; a first exam after 4
weeks and a second exam at the end of the course about the
subjects/lectures of weeks 5-8 (60% in total for two exams)

Sufficient grades (>5.5) for the presentation, the essay, as well as the
exams are required in order to pass the course.
Students need to acquire sufficient grades for both written exams. Exams
cannot be averaged to obtain a sufficient grade.

There is ONE resit in February that covers the contents of ALL 8 weeks
(no interim resit).

Vereiste voorkennis

All students following the masters program in Neurosciences at the VU
are required to take this course.
External candidates are allowed, if accepted by the course
coordinator (


Course slides and provided research papers


- MSc Neurosciences students
- External students with background and interest in (Clinical)
Enrollment by external students needs to be approved by the course
coordinator (e-mail:

Overige informatie

This course is coördinated by: dr. C. Vriend (Chris) and dr. D.P.Bakker

Afwijkende intekenprocedure

Enrolment in vu-net.

Aanbevolen voorkennis

For external candidates, some (basic) knowledge on the brain, brain
disorders and
neuroanatomy is highly recommended.
Recommended read: Neuroanatomy: an illustrated colour text (5th edition,
Crossman & Neary, ISBN 9780702054051)

Algemene informatie

Vakcode AM_1005
Studiepunten 6 EC
Periode P2, Ac. Jaar (sept)
Vakniveau 400
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator C. Vriend
Examinator dr. D.P. Bakker
Docenten M.M. Schoonheim
dr. D.P. Bakker

Praktische informatie

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