Animal Experiments for Human Movement Sciences

2019-2020
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Aim of this course is to prepare research master students who are going
to perform animal ex-periments for their research project in their
second year. The course is focused on the respect-ful and responsible
use of laboratory animals in Human Movement Sciences related research.
Refinement of techniques, reduction in the number of animals used and
replacement wherever possible by non-sentient systems will be guiding
principles.

Inhoud vak

In this course, the students are educated and trained in the principles
and practical skills that are essential for the humane use and care of
laboratory animals and for the quality of research. The two-year
Research Master program Human Movement Sciences: Sport, Exercise &
Health aims at training for research on the cutting edge of fundamental
and clinical human movement sciences that tries to integrate fundamental
scientific knowledge with relevant questions from clinical and sports
practice. The first year is dedicated to preparation for research. The
second year is fully dedicated to a research internship of your own
choice. The human movement sci-ences cover a great variety of subjects
and scientific disciplines stretching from molecular biol-ogy and muscle
physiology to cognitive neuroscience and human motor behavior. This also
in-volves several experimental approaches, ranging from in vitro work on
for example cultured cells to in situ and in vivo studies using live
animals, as well as experiments on human subjects. Appropriate education
and training of all those engaged in the use of live vertebrate animals
for scientific purposes is required. To prepare students for a research
career using animal models, the course Animal Experiments for Human
Movement Sciences is offered to those students that are accepted for a
research internship involving animal experiments.

Onderwijsvorm

This course consist of three major parts. All lectures and lab classes
are obligatory.
1. Course on Laboratory Animal Science (3 EC) as coordinated by the
Division of Animal Welfare & Laboratory Animal Science, Utrecht
University.
2. Training on handling animals, fluid injections and anesthesia, as
well as general microsurgical techniques (1.5 EC).
3. Training of project specific surgical skills (1.5 EC)

Toetsvorm

Part 1: written exam (grade 1-10); The student has a maximum of two
opportunities to pass the written exam. There is no second chance for
this course.
Part 2: practical exam (pass/fail); Assessment by Laboratory Animal
Welfare Officer of VU/VUmc and Animal Research Coordinator of Laboratory
for Myology.
Part 3: practical exam (pass/fail); Assessment by laboratory technician
and research internship supervisor.
A student passes for this course only if all parts were graded by a mark
>6 or by a pass.

Vereiste voorkennis

- The student should have training which meets the legal requirements of
18 ECTS biological basic subjects (of which 7.2 ECTS anatomy/zoology and
7.2 ECTS physiology).
- The student has been accepted by a scientific staff member of the MOVE
research institute Amsterdam for a research project that will involve
animal experiments.
- Ethical approval for the specified experiments has been granted by (or
at least submitted to) the Central Animal Testing Committee (‘Centrale
Commissie Dierproeven’), the central body which alone is authorized to
grant project licenses to perform animal procedures.
- Admission for this course requires proof of the above, including a
short description of the involved animal experiments, sent to the course
coordinator, who will decide if the course is appropriate for the
internship.

Literatuur

Part 1: Course on Laboratory Animal Science
The theoretical part of the course is covered by a multi-author textbook
(which has been trans-lated into several other languages): L.F.M. van
Zutphen, V. Baumans and A.C. Beynen (eds.), Principles of Laboratory
Animal Science: A contribution to the humane use and care of animals and
the quality of experimental results, Elsevier Science Publishers,
Amsterdam, 2003 (4th ed.) Also a CD-ROM Humane Endpoints in Laboratory
Animal Experimentation is used and additional information is given with
hand-outs from presentations, etc.

Part 2: Training anesthesia and fluid injections, as well as general
microsurgical techniques
- Information for handling and fixing mouse and rat (Amsterdam Animal
Research Center, VU University; in Dutch).
- Manual of Microsurgery on the Laboratory Rat, Part I. Remie R. et al.
(1990). Chapters 3, 4, and 7.
- Chirurgische Knotentechnik. Ethicon; a Johnson & Johnson Company
(2009).

Part 3: Training of project specific surgical skills
- General laboratory practice ("Algemene labvoorschriften") and those
specific for the lab.
- Animal anatomy, those structures that are involved in the project
specific surgery.
- Surgical protocol specific for the research project.

Doelgroep

The course is an optional part of the Research Master program
Fundamental and Clinical Human Movement Sciences. For those students
that are going do a research internship involving animal experiments and
also have the strong motivation to pursue a scientific career using
animal models, it is essential to get trained in the theory, ethics,
methodological design and practice of animal experimentation.

Afwijkende intekenprocedure

To sign up for this course, students should first make an appointment with the course coordinator (Huub Maas, h.maas@vu.nl)

Algemene informatie

Vakcode B_ANIMEXP
Studiepunten 6 EC
Periode Ac. Jaar (sept)
Vakniveau 500
Onderwijstaal Engels
Faculteit Fac. der Gedrags- en Bewegingswetensch.
Vakcoördinator dr. H. Maas
Examinator
Docenten

Praktische informatie

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