CVR challenges: Pathological interactions between the cardiovascular and other organ systems

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

1. To understand clinical presentation of heart failure with reduced and
preserved ejection fraction
2. To understand pathomechanisms of heart failure with reduced and
preserved ejection fraction
3.To understand pathomechanisms of arrhythmias
4.To understand interaction of diabetes and cardiovascular syndromes
5.To understand ischemia and its cause and effects
6.To understand clinical presentation and pathomechanisms of genetic
7.To understand mutual cross-talk between the heart and kidney
8.To understand interaction between the lungs and the right heart
9.To have an overview of current diagnosis and treatment options and
future challenges related to objectives 1-8

Inhoud vak

Cardiovascular failure is the most common cause of hospitalization in
Western societies and, despite advances in treatments, the prognosis of
patients with heart failure remains poor. Progressive deterioration in
vascular and myocardial function is a crucial feature of chronic heart
failure and is the result of many different pathological processes
affecting the vessels and muscle of the heart. As a result of changes in
lifestyle–leading to obesity, hypertension, and diabetes–cardiac and
vascular problems now frequently arise at a relatively young age. As
life expectancy has increased, this aging population has become
characterized by chronic cardiovascular disease, causing reduced quality
of life and increased healthcare costs.
During this minor basic (preclinical) and clinical scientists will
highlight the recent advancements in understanding causes of
cardiovascular disease, which not only involve the heart and
vasculature, but also the complex interactions between other organ
systems (lungs, kidneys). A brief overview will be given on the
physiology of organ systems, after which pathophysiologic mechanisms of
different forms of heart failure, atrial fibrillation and genetic
cardiomyopathies will be discussed. In addition, emphasis will be put on
the heart-kidney and heart-lung interactions, and the relation between
obesity and diabetes and cardiovascular disease. The minor is composed
of various topics, which are related to research themes within the
Amsterdam Cardiovascular Sciences (ACS) research institute. In
interactive lectures and working groups, knowledge will be gained about
state-of-the-art diagnosis tools (imaging, biomarkers), and current and
new treatment options.


Interactive lectures, practicals (visits to laboratories and clinical
settings), working groups, writing assignments


For each of the 9 learning objectives an assignment will be formulated.

Method of assessment (min. 5 independent exams)
2 CAT’s with open questions in English, 1 individual discussion paper, 1
presentation of the protocol, 1 written protocol in a group of 4
students and presence at workgroups and guest lectures. Presentations of
students in workgroups will get feedback from the teachers.
Assignments will be used for working groups to practice scientific
debating in English.

Assignment examples:
Pro-con debate on clinical significance of vascular calcification
Difference between HFPeF and HFReF
Causes and therapeutical options in AF
Measurements of arterial stiffness in human and identify factors that
modify this.
Concepts of atherosclerosis (inflammation, crystallopathy etc)
Team-based learning meeting covering type 4 cardiorenal syndrome
Presentation on several individual pathway that are involved in type 4
cardiorenal syndrome.

Toelichting Canvas

This minor is supported by a corresponding CANVAS course, which contains
all of the required information of this minor including an overview of
the required articles and assignments. The CANVAS course will also be
used to post announcements relevant to the minor. You will automatically
have access to the CANVAS course.

Aanbevolen voorkennis

Knowledge on basic functions of heart and vessels is recommended. The
knowledge of anatomy of the heart, basic electrophysiology (ECG) and
flow patterns in the heart are considered basic knowledge.

Algemene informatie

Vakcode M_BCVRC19
Studiepunten 24 EC
Periode Semester 1
Vakniveau 300
Onderwijstaal Engels
Faculteit VUmc
Vakcoördinator prof. dr. J. van der Velden
Examinator prof. dr. J. van der Velden
Docenten prof. dr. J. van der Velden
dr. I. Vergroesen
prof. dr. B.J.J.M. Brundel
dr. I. Vergroesen
dr. R.B. van Loon
prof. dr. T.H. Muller
R.A. Boon MA
dr. H.J. Bogaard

Praktische informatie

Voor dit vak kun je niet zelf intekenen; het onderwijsbureau van jouw faculteit tekent je in.

Werkvormen Werkcollege, Studiegroep, Practicum

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