Medical research to clinical practice

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

1. Students know which steps to follow to set-up and perform a medical
2. Students can analyze and interpret their own research data;
3. Students can present the findings of their research in an appropriate
4. Students know how research is being performed at a medical department
of an (academic) hospital;
5. Students can perform their own medical research.

Inhoud vak

Nowadays, working as a physician means that you need to understand
medical research, as this is the key to good clinical practice. But not
only having the knowledge, but also being able to apply medical research
is important. Therefore, the minor Medical Research into Clinical
Practice has been developed. In this minor students learn how to set-up
medical research, how to analyze the retrieved data as a tool to answer
the research question of interest, and learn what the implications are
for clinical practice. This minor is a combination of theory and
practice as the student will be placed at a medical department to
perform a medical research project on his/her own, in one of the
research institutes of the VU medical center (or other locations if
possible). For the students of the VUmc School of Medicine, the bachelor
thesis consists of the paper that will be written based on their own
research, which they have performed during the four months of this
minor. The minor can be divided in three major divisions: the set-up,
the analysis and the interpretation.
Once every two weeks, the student will have a meeting with their
supervisor from the department of Epidemiology and Biostatistics, in
small groups during the Monday Morning Meetings, and once every two
weeks, question hours are organized in which the students can ask help
with their research project from prof. dr. Jos Twisk, dr. Marieke ter
Wee and/or dr. Martijn Heymans.

Besides the teaching and practical hours, the student will be working on
their own research for 2 days at the medical department during the whole
period of 4 months.

The set-up: Setting up research
In the first weeks of the minor Medical Research into Clinical Practice,
the student will learn more about how to set-up different types of
studies and about the pitfalls accompanying the different type of
studies. Besides that, the students will also learn how to perform
systematic reviews, how to assess the quality of measurement
instruments, and how to perform qualitative research and
cost-effectiveness studies. Finally, the students will learn how to
write a research proposal. This part is examined with a research
proposal and a theoretical exam.

The analysis: Analyzing data to retrieve an answer to the research
Statistical analyzes are a tool that is needed to retrieve an answer to
the research question that is being studied. Therefore, we pay a lot of
attention on how to analyze data. We start off with a recap of linear,
logistic and Cox regression analyses. Furthermore, the students will
learn how to deal with missing data, how to build and validate
prediction models, and how to perform mediation analyses. This first
part is examined with a combined theoretical and practical exam. ¶
In the second part, the students will learn how to analyze correlated
data, how to analyze longitudinal data and how to analyze data retrieved
from RCTs.
This part will be examined with a practical exam and a theoretical

The interpretation: Interpretation of the findings and implications for
clinical practice
In the last weeks of this minor, we will focus on how results of medical
research are used in development of guidelines and prediction rules that
are used in the clinical practice. We will focus on the impact of big
data and why this is becoming more important in medical research. The
students will learn how costs impact the health care system, how to deal
with the press, how to assess the quality of published articles, and how
to convert the results of medical research into a poster and
This part is examined by a poster presentation.


Lectures, practicals, working groups


Four theoretical exams, Research proposal, 2 practical exams, poster
presentation. All practical and theoretical exams are open book exams
and with open ended questions. (min. 5 independent exams)


• A Quick Guide on How to Conduct Medical Research. From Set-up to
Publication. ISBN: 9789036822473
• Applied Mixed model Analyses. ISBN: VOLGT
• Applied Longitudinal Analyses for Epidemiology. ISBN: 9781107699922


Bachelor’s students of VUmc School of Medical Sciences and external (and
international) students with a (bio)medical background.

Aanbevolen voorkennis

Knowledge on descriptive statistics and regression analyses (MWO1 and
MWO2 – Bachelor courses B1 and B2) is recommended. Regression techniques
(linear, logistic, Cox) and SPSS.

Algemene informatie

Vakcode M_BMRTCP19
Studiepunten 24 EC
Periode Semester 1
Vakniveau 300
Onderwijstaal Engels
Faculteit VUmc
Vakcoördinator M.M. ter Wee-Zaal
Examinator M.M. ter Wee-Zaal
Docenten prof. dr. J.W.R. Twisk

Praktische informatie

Voor dit vak kun je niet zelf intekenen; het onderwijsbureau van jouw faculteit tekent je in.

Werkvormen Werkcollege, Studiegroep, Practicum

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