Macroscopic, microscopic and pathological anatomy of the mouse

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Doel vak

Animal experiments, especially using mice and rats, are an important
part of many PhD projects. A better understanding of rodent anatomy,
histology, pathology, genetics, wellbeing, and a proper perspective of
the difference of rodent models versus human physiology can improve the
quality of these experiments substantially.

Course participants are introduced into various aspects of research with
rodents. The aim is to increase awareness of the physiology and genetics
of experimental animals, thereby enabling better planning and execution
of animal research.

After finishing this course, students:
- can describe and demonstrate the anatomy and histology of major organs
of the mouse;
- are able to choose mouse strains suitable for their research;
- can interpret histological and imaging data;
- can judge behaviour and deduce wellbeing of experimental animals;
- can design mouse experiments that are better suited for translation to

Inhoud vak

The subjects covered are:
1.Anatomy (dissection) of adult male and female mice
2.Microscopic and pathological anatomy of rodent tissues and organs
3.Dealing with pathologically changed animals
4.Developmental and neuro-anatomy: comparison of rodent and human
5.Imaging the mouse (MRI and PET/SPECT)
6.Gene targeting, transgenic strategies, and generation of mouse models
7.Mouse breeding and querying the Jax phenotype database
8.Rodent behaviour and experimental outcomes


Master students have to make an assignment.


This is a PhD-students' course organized by the OOA. OOA courses are
open for Master Oncology students as optional courses under certain

Overige informatie

"For further information contact:

Dr. J.E. Seppen
Course coordinator
Tytgat Institute for Liver and Intestinal Research

Dr. E.A.J. Reits
Course coordinator
Department of Cell Biology & Histology


Afwijkende intekenprocedure

This course is organised and coordinated by the Tytgat Institute for Liver & Intestinal Research and the Department of Cell Biology & Histology, in collaboration with the Oncology Graduate School of Amsterdam (OOA, Onderzoekschool Oncologie Amsterdam). The course is incorporated in the course programme of the AMC Graduate School for Medical Sciences. Participants follow lectures in the morning and learn hands-on skills in the afternoon. The course lasts 9 days and takes place once a year. Attending both weeks is recommended, however, it is possible to attend only the first week (mouse anatomy, histology, pathology, and imaging) or the second week (mouse genetics, behaviour and scaling). Study load: 72 hours, which is comparable to 2.6 ECTS For further information and registration contact: Ms Mona Brox Edvardsen Tytgat Institute for Liver and Intestinal Research email:

Algemene informatie

Vakcode M_OMAMIPAT18
Studiepunten 3 EC
Periode P5
Vakniveau 500
Onderwijstaal Engels
Faculteit VUmc

Praktische informatie

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