Replacement Refinement and Reduction of Animal Experiments in Biomedical Research: From Origins to Implementation

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Lecture topics:

• The evolution of drug safety testing and ethical issues related to
animal use.
• Russell and Burch and the origins and implementation of the 3Rs.
• Cell culture including primary cells, cell lines, and induced
pluripotent Stem Cells (iPSC): generation, culture.
• Toxicity assays, Molecular Toxicology and Systems Biology (omic)
• Regulation, validated alternatives and future aspects.

Inhoud vak

The course provides an understanding of issues involved in the
development of alternative to animals for hazard and risk assessment of
chemicals. The lectures will cover the 3R principles, i.e. REPLACEMENT,
REFINEMENT AND REDUCTION of Animal use in the life sciences, first
coined by WMS Russel and RL Burch in 1959. Today the 3R principle is a
central part of the Directive 2010/63/EU regulating animal testing and
thus integral part of animal protection law and lab-animal handling in
all EU member states.


Teaching will be through lectures and course work.


Course work assessment and exam.

Vereiste voorkennis

There are no entry requirements.


The Three Rs and the Humanity Criterion: An Abridged Version of the
Principles of Humane Experimental Technique by W.M.S. Russell and R.L.
Burch, Michael Balls

Bal-Price, A., Jennings, P., 2014. In Vitro Toxicology Systems.


mDDS, mCHEM, mBMS and PhD - AIMMs, but others welcome

Aanbevolen voorkennis

There is no background needed.

Algemene informatie

Vakcode XM_0066
Studiepunten 6 EC
Periode P3
Vakniveau 400
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator prof. dr. P. Jennings
Examinator prof. dr. P. Jennings
Docenten prof. dr. P. Jennings

Praktische informatie

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