Advanced Analytical Sciences in Drug-Related and Clinical Environments

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Giving a clear description on the instrumental and bio-analytical
techniques and strategies that are used in biomedical and clinical
analysis and diagnostics.

Inhoud vak

The course will start with discussing the basics of bio-analytical and
clinical chemistry focusing on decision trees (strategic decisions) that
can be used during the method development and optimization of analytical
procedures to determine both endogenous and exogenous compounds in
complex biological samples. Approaches and procedure with respect to
sampling, sample preparation, separation, as well as immunological and
enzymatic procedures will be dealt with. Special attention will be given
to the simultaneous determination of parent compounds in the presence of
their degradation products, metabolites, precursors and/or structure
analogues. In addition to target finding, screening procedures in the
fields of metabolomics, proteomics, etc . will be highlighted. During
the course case studies will be used to clarify the decisions that have
to be taken using advanced bio-analytical and clinical determinations.


Lectures and tutorials


Written examination


M.L. Bishop, E.P. Fody, L.E. Schoeff, Clinical Chemistry, Wolters
Kluwer, Philadelphia, Sixth edition, 2010.


mDDS, mMNS, mCH-AS (however, not in combination with Bio-Analysis &
Clinical Diagnostics)

Overige informatie

This course can not be followed in combination with Bio-Analysis &
Clinical Diagnostics.

Aanbevolen voorkennis

Basic knowledge on analytical chemistry, biochemistry, chromatography,
electrophoresis and mass spectrometry

Algemene informatie

Vakcode XM_0068
Studiepunten 6 EC
Periode P3
Vakniveau 400
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator prof. dr. G.W. Somsen
Examinator prof. dr. G.W. Somsen
Docenten prof. dr. G.W. Somsen

Praktische informatie

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Werkvormen Hoorcollege

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