Principles of Systems Biology

Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

This course aims to give a broad overview over topics related to Systems
Biology. In addition it intends to fill gaps in your background
knowledge to ensure you can take more advanced systems biology courses.

Inhoud vak

Theoretical topics:
- The two branches of systems biology
- Data structure, geometrical mapping, PCA, distance metrics, clustering
- Cellular composition, diffusion, time scales, rates
- Mass-action, mass balances, reactions, equilibria, stable/unstable
steady states equilibrium binding, affinity, conformational change,
ultrasensitivity, transduction cascades, autoregulation, mutual
inhibition/activation, bistability, feed-forward loops, steady state
metabolism, regulation of metabolism and regulation by demand

- Exercises during/in between lectures in which methods of systems
biology will be applied to several topics.

- Conversion classes
Depending on their background, students will also be assigned to one out
of three deficiency classes where they will be working to fill gaps in
their knowledge in mathematics, programming and/or biology.


- Lectures (two hour lecture in the morning, two days per week)
- Computer- and modelling practicals


Exam of the Systems Biology subjects


This course may only be followed by students enrolled in the BSc minor
Bioinformatics and Systems Biology.

Algemene informatie

Vakcode X_428566
Studiepunten 6 EC
Periode P1
Vakniveau 300
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. D. Molenaar
Examinator dr. D. Molenaar
Docenten dr. D. Molenaar

Praktische informatie

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Werkvormen Werkcollege, Deeltoets extra zaalcapaciteit, Hoorcollege, Computerpracticum

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