Doel vakThe overall aim of this course is to introduce the students to the basic
mathematical language required to describe atoms, electrons, and
molecules by means of the quantum mechanical description of matter. On
the one hand, the topics covered in the course are required to gain a
better understanding of the physical basis of important chemical
properties and physical reactions that appear frequently in a medical
context. On the other hand, this formalism also allows us to translate
quantum mechanical concepts into measurable quantities that can then be
used for medical applications, such as positron therapy or magnetic
nuclear resonance. In this course, we will therefore cover a number of
topics which range from fundamental quantum mechanics to the
corresponding applications in medical sciences.
Inhoud vakThe contents of the course are the following:
*) It starts with a introduction to the quantum world, relevant for the
description of small objects like atoms, molecules, and electrons. This
will require presenting important concepts such as the wave-particle
duality, the De Broglie relations, and the Heisenberg uncertainty
principle of quantum mechanics.
*) We will then move to present the fundamental equation of motion of
quantum theory, namely the Schroedinger equation, and apply it to a
number of important systems such as the particle in a box, the hydrogen
atom, the harmonic oscillator, and the hydrogen atom.
*) The course will then explore next how quantum theory allows
describing the binding mechanisms between atoms that lead to the
formation of molecules. In this context, we will study the valence bond
theory, the molecular orbital theory, the concepts of hybridization and
molecular interactions, hydrogen bridges, and then Huckel theory.
*) In the last part of the course we will consider molecular
spectroscopy, with emphasis on its medical applications, and we will end
up describing the underlying physics of one of the most popular tools in
medical imaging, namely Nuclear Magnetic Resonance (NMR), illustrating
the deep connection between the quantum description of nature and recent
breakthroughs in medical science and tools.
OnderwijsvormLectures and tutorials, together with homework assignements
ToetsvormDeeltoets, Schriftelijk tentamen.
Vereiste voorkennisFysica en Medische Fysica 1/2
LiteratuurPhysical Chemistry, 10th edition (Oxford University Press), P. Atkins,
J.De Paula. Note that a new edition (11th) has also been released.
|Faculteit||Faculteit der Bètawetenschappen|
|Vakcoördinator||dr. J. Rojo|
|Examinator||dr. J. Rojo|
dr. R. Gerritsma
dr. J. Rojo
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