Inleiding systeembiologie

2019-2020

Doel vak

The properties of cells and higher levels of organisation emerges out of
molecular interactions within huge networks. Examples of such molecular-
reaction networks are: metabolism, signal transduction, and gene
networks. Systems biology studies the principles of such networks using
quantitative experiments, computer modelling and theory.

The aim of this course is to introduce the students to the approach
taken in systems biology. We will study a number of theoretical findings
of systems biology about the dynamics and regulation of molecular
networks inside living cells using small "toy" mathematical models and
basic principles of biochemistry and physics.

Inhoud vak

The following topics will be discussed:
- mass-action kinetics and basic enzyme kinetics
- thermodynamic equilibrium and steady state
- dynamics of simple systems
- protein complex formation, allosteric interactions, and cooperativity
- ultrasensitivity of small signalling circuits
- supply and demand as coarse-grained method to dissect regulation of
metabolism
- robust integral feedback control
- role of positive and negative feedback

The practicals involve answering exercises and basic plotting of results
of mathematical models.

Onderwijsvorm

lecture series and supervised work groups in which assignments from the
syllabus are made

Toetsvorm

Written exam (open book). Learned techniques will have to be applied to
new systems.

Vereiste voorkennis

Basic knowledge of mathematics (differential equations, differentiation,
formula manipulation), (bio-)chemistry, and cell biology.

Literatuur

Syllabus (gratis via BB)

Doelgroep

Students interested in the intricate workings of biological systems and
not afraid of basic equations describing the properties of dynamic
systems

Algemene informatie

Vakcode X_401042
Studiepunten 3 EC
Periode P4
Vakniveau 300
Onderwijstaal Nederlands
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator prof. dr. B. Teusink
Examinator prof. dr. B. Teusink
Docenten prof. dr. B. Teusink
prof. dr. F.J. Bruggeman

Praktische informatie

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