Dynamics of Biomolecules and Cells

2018-2019
Dit vak wordt in het Engels aangeboden. Omschrijvingen kunnen daardoor mogelijk alleen in het Engels worden weergegeven.

Doel vak

Life is, by its very definition, a dynamic quantity. In this course an
overview is given of current scientific research fields that study the
dynamic processes that take place in biomolecules, membranes and cells
and are indispensable for biological functionality. This course aims to
highlight the 'what', 'why' and 'how' of these research fields: what are
the established and new biological insights, why are these insights
important, and how are these results being obtained.

Learning objectives
* Understand the physics underlying the biophysical research methods
featured in this course
* Be able to explain how these methods can be exploited to address
specific biological problems and identify strengths and weaknesses of
methods in biological context
* Critically reflect on your understanding of methods application in
assigned literature and formulate relevant questions
* Analyze scientific literature that uses the discussed methodologies to
addresses biological problems and reflect on suitability of used methods
* Communicate and present your literature analysis and critically
reflect on analyses by other students

Inhoud vak

The significance of small movements to large-scale and slow
reorganizations are being discussed as well the experimental techniques
employed.
- DNA processing and dynamics (techniques: optical tweezers, AFM,
tethered particle motion, magnetic tweezers). DNA structure and
stability, DNA/RNA polymerase, DNA architectural proteins, DNA repair.
- Protein dynamics (techniques: ultrafast spectroscopy, Infrared and
Raman spectroscopy, single-molecule fluorescence). Photoactive proteins,
light-driven enzymes, Motor proteins, optogenetics.
- Membrane dynamics and remodeling (techniques AFM, single molecule,
electron microscopy). Photosynthesis, crowding and membrane protein
diffusion, Neuroimaging.
-superresolution microscopy

Onderwijsvorm

Lectures, guest lectures, literature essay and assignments, oral
literature presentation

Toetsvorm

- Literature assignments
- Essay (literature or research proposal)
- Oral literature presentation

Vereiste voorkennis

BSc. Physics, BSc. Medical Natural Sciences, BSc Chemistry or comparable

Literatuur

Notes, handouts and papers.

Doelgroep

mMNS-PoL, mPhys-LSBP, mPhys-PLH

Algemene informatie

Vakcode X_422583
Studiepunten 6 EC
Periode P4
Vakniveau 400
Onderwijstaal Engels
Faculteit Faculteit der Bètawetenschappen
Vakcoördinator dr. ir. I. Heller
Examinator dr. ir. I. Heller
Docenten dr. ir. I. Heller
prof. dr. J.T.M. Kennis

Praktische informatie

Voor dit vak moet je zelf intekenen.

Voor dit vak kun je last-minute intekenen.

Werkvormen Hoorcollege
Doelgroepen

Dit vak is ook toegankelijk als: